{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:59Z","timestamp":1787793899391,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["20070025 C"],"award-info":[{"award-number":["20070025 C"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Patients with uveal melanoma (<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>) undergo lifelong follow\u2010up as metastases can occur more than 20\u00a0years after diagnosis. Little is known about the quality of life (QoL) of <jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content> survivors over such an extended period. To investigate their QoL, we used various estimating factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of patients diagnosed and treated for <jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content> with regularly scheduled follow\u2010up visits was asked to fill in a European Organization for Research and Treatment of Cancer (EORTC) questionnaire comprised of the <jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010C30 and <jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OPT<\/jats:styled-content>30 modules. An additional open question examined other changes in the patients\u2019 lifestyle since diagnosis. Independent demographic and medical data were collected from patient records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and thirty\u2010two of 294 patients agreed to complete the questionnaire. General QoL correlated highly with the eye\u2010related QoL. Statistically significant higher QoL was associated with tumours not involving the ciliary body, and with better best\u2010corrected visual acuity (BCVA). A subgroup of 39% of the patients reported severe disability affecting eye\u2010related tasks. Thirty\u2010three per cent were highly concerned about various aspects of their future health. Patients who underwent enucleation reported lower eye\u2010related QoL and described problems related to body image in response to the open question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>General QoL of <jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content> patients is only slightly affected by their malignancy. However, body image and psychosocial adjustment are major issues involved in evaluating QoL. Continuous long\u2010term psychosocial treatment is needed from the time of diagnosis in a subgroup of patients suffering from eye\u2010related disabilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13655","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T14:58:51Z","timestamp":1516892331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term uveal melanoma survivors: measuring their quality of life"],"prefix":"10.1111","volume":"96","author":[{"given":"Shahar","family":"Frenkel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Rosenne","sequence":"additional","affiliation":[{"name":"Department of Social Work Hadassah\u2010Hebrew University Medical Center Jerusalem 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