{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:24:23Z","timestamp":1787505863244,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30\u2010EY026877"],"award-info":[{"award-number":["P30\u2010EY026877"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n To assess the within\u2010treatment efficacy of hot compresses (\n HC<\/jats:styled-content>\n ),\n HC<\/jats:styled-content>\n plus tobramycin (Tobrex) and\n HC<\/jats:styled-content>\n plus tobramycin\/dexamethasone (Tobradex) for chalazia treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Design: Multicentre, randomized clinical trial (ClinicalTrials.gov identifier,\n NCT<\/jats:styled-content>\n 01230593). Setting: Two clinical sites in New York and two clinical sites in Ontario. Study Population: A total of 149 patients with one or more chalazia on separate eyelids randomly assigned to receive\n HC<\/jats:styled-content>\n (n\u00a0=\u00a050),\n HC<\/jats:styled-content>\n plus tobramycin (n\u00a0=\u00a050) or\n HC<\/jats:styled-content>\n plus tobramycin\/dexamethasone (n\u00a0=\u00a049). Intervention: 4\u20136\u00a0weeks of assigned treatment. Patients were measured for chalazion horizontal width and surveyed for pain and treatment satisfaction levels. Main outcome measures: Primary outcome was complete resolution (100% size reduction). Secondary outcomes were size change in millimetres and patient reported pre\u2010 and post\u2010treatment pain and satisfaction levels.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the intention\u2010to\u2010treat (\n ITT<\/jats:styled-content>\n ) population, complete resolution occurred in 36 (18%) lesions total, 13 (21%) treated with\n HC<\/jats:styled-content>\n , 12 (16%) with\n HC<\/jats:styled-content>\n plus tobramycin and 11 (18%) with\n HC<\/jats:styled-content>\n plus tobramycin\/dexamethasone, with no significant difference between them (p\u00a0=\u00a0.78). Individually by paired t\u2010test, there were statistically significant post\u2010treatment mean size differences:\n HC<\/jats:styled-content>\n 1.20\u00a0mm (p\u00a0<\u00a00.001),\n HC<\/jats:styled-content>\n plus tobramycin 1.69\u00a0mm (p\u00a0<\u00a0.001) and\n HC<\/jats:styled-content>\n plus tobramycin\/dexamethasone 1.54\u00a0mm (p\u00a0<\u00a00.001), but no significant difference between them (p\u00a0=\u00a0.61). Lesions that completely resolved had a statistically significant lower pretreatment duration (1.5\u00a0months) compared to lesions that did not completely resolve (2.2\u00a0months) (p\u00a0=\u00a0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Hot compresses (HC) alone or in combination with tobramycin or tobramycin\/dexamethasone drops and ointment are all effective first\u2010line treatment options for chalazia. However, physicians may consider moving directly to the use of more invasive therapies, such as incision and curettage or steroid injections, for chalazia that have been present for more than 2\u00a0months, as older lesions are less likely to resolve with conservative therapies alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.13675","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T13:10:48Z","timestamp":1516108248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Conservative therapy for chalazia: is it really effective?"],"prefix":"10.1111","volume":"96","author":[{"given":"Albert Y","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Ophthalmology Elmhurst Hospital Center Elmhurst New York USA"},{"name":"Stanford University Medical Center Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-7347","authenticated-orcid":false,"given":"Kalla A","family":"Gervasio","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Ophthalmology Elmhurst Hospital Center Elmhurst New York USA"},{"name":"Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie N","family":"Gergoudis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Ophthalmology Elmhurst Hospital Center Elmhurst New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Ophthalmology Elmhurst Hospital Center Elmhurst New York USA"},{"name":"Memorial Sloan Kettering Cancer Center New York New York USA"},{"name":"Harvard Medical School Harvard University Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H","family":"Oestreicher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harvey","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Department of Surgery McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.11.037"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.10.026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6405.1595"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830590946907"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2005.00982.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130560036"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1662"},{"key":"e_1_2_6_9_1","first-page":"311","article-title":"Management of chalazia in general practice","volume":"38","author":"Gilchrist H","year":"2009","journal-title":"Aust Fam Physician"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01617.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700603"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(80)35250-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199603630-00019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01676830802623174"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-9904-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13136"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:33:39Z","timestamp":1695026019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/aos.13675"],"URL":"https:\/\/doi.org\/10.1111\/aos.13675","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]},"assertion":[{"value":"2017-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}