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This included Early Treatment of Diabetic Retinopathy Study best\u2010corrected visual acuity, visual field testing, colour vision testing, slit\u2010lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>). In selected cases, fluorescein angiography was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serous subretinal fluid (<jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content>) developed in all patients, within a time frame of 9\u201327\u00a0days after the start of treatment. The fovea was involved in six of eight patients (75%). None of the patients with foveal <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content> [excluding a patient who developed a bilateral retinal vein occlusion (<jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>)] experienced visual symptoms. Subretinal fluid (<jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content>) decreased or resolved in all patients, despite continuation of study medication in six of eight patients (75%). Complaints in the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> patient (13%) consisted of experiencing a dark fleck in the inferior part of the visual field of the right eye 1\u00a0week after the start of treatment, due to an <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>. Subsequent intravitreal bevacizumab treatment resulted in functional and anatomical improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with metastatic <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> who are treated with the <jats:styled-content style=\"fixed-case\">MEK<\/jats:styled-content> inhibitor pimasertib are at high risk of development of ocular adverse events including serous retinopathy and possibly <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>, stressing the need of adequate ophthalmological follow\u2010up including <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> during administration of pimasertib, despite the fact that <jats:styled-content style=\"fixed-case\">SRF<\/jats:styled-content> generally does not lead to ophthalmological complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13677","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T18:10:54Z","timestamp":1516126254000},"page":"712-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pimasertib\u2010associated ophthalmological adverse events"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6351-7942","authenticated-orcid":false,"given":"Elon H.C.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim H.J.","family":"Kruit","sequence":"additional","affiliation":[{"name":"Department of Internal Oncology Erasmus University Medical Centre\u2010Daniel den Hoed Cancer Centre Rotterdam 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