{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:35:04Z","timestamp":1788435304203,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005426","name":"Association for Research in Vision and Ophthalmology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Structural and physiological abnormalities have been reported in the retina in patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). Retinal oximetry has recently detected changes in retinal oxygen metabolism in Alzheimer\u2032s disease and mild cognitive impairment. Our goal was to determine whether oxygen saturation in retinal blood vessels of patients with patients is different from that of a healthy population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oxygen saturation of haemoglobin was measured in retinal blood vessels, using imaging with spectrophotometric noninvasive retinal oximeter. Eight<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>patients with history of optic neuritis were measured and compared to 22 healthy individuals matched in age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Venular oxygen saturation was increased in patients with<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>compared to healthy individuals (70.7\u00a0\u00b1\u00a03.4% versus 66.2\u00a0\u00b1\u00a04.7; p\u00a0=\u00a00.021, mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>). The arteriovenous (AV) difference was lower in patients with<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>compared to healthy (26.6\u00a0\u00b1\u00a03.6% versus 30.5\u00a0\u00b1\u00a04.8%; p\u00a0=\u00a00.049). There was no difference measured in arterioles when patients with<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>(97.3\u00a0\u00b1\u00a01.7%) and healthy individuals (96.7\u00a0\u00b1\u00a02.8%) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased venular oxygen saturation and lower AV difference in patients with<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>may indicate reduced oxygen uptake. This may be due to less oxygen demand following atrophy and may be a useful objective biomarker for<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Further studies are needed to confirm and expand these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13682","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T18:10:52Z","timestamp":1516126252000},"page":"528-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Retinal oximetry is affected in multiple sclerosis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-2353","authenticated-orcid":false,"given":"Anna Bryndis","family":"Einarsdottir","sequence":"first","affiliation":[{"name":"Department of Neurology Landspitali \u2010 National University Hospital Reykjavik Iceland"},{"name":"Department of Neurology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof Birna","family":"Olafsdottir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landspitali 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Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12374"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150457"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12156"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9912"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3233\/JPD-130306","article-title":"Optical coherence tomography in Parkinson's disease: is the retina a biomarker?","volume":"4","author":"Lee JY","year":"2014","journal-title":"J Parkinsons Dis"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"P5.307","DOI":"10.1212\/WNL.84.14_supplement.P5.307","article-title":"Retinal oximetry\u2010derived biomarkers of metabolic dysfunction in MS","volume":"84","author":"Lucero 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