{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:51:01Z","timestamp":1792363861624,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize cat\u2010scratch disease (<jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content>) ocular manifestations and visual outcome and evaluate the effect of systemic antibiotics and corticosteroids on final visual acuity (<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre retrospective cohort study. Medical records of 86 patients with ocular disease (107 eyes) of 3222 patients identified in a national <jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content> surveillance study were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 35.1\u00a0\u00b1\u00a014.2\u00a0years. Median follow\u2010up was 20\u00a0weeks (range 1\u2013806\u00a0weeks). Of 94\/107 (88%) eyes with swollen disc, 60 (64%) had neuroretinitis at presentation, 14 (15%) developed neuroretinitis during follow\u2010up, and 20 (21%) were diagnosed with inflammatory disc oedema. Optic nerve head lesion, uveitis, optic neuropathy and retinal vessel occlusion were found in 43 (40%), 38 (36%), 34 (33%) and 8 (7%) eyes, respectively. Good <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> (better than 20\/40), moderate vision loss (20\/40\u201320\/200) and severe vision loss (worse than 20\/200) were found in 26\/79 (33%), 35\/79 (44%) and 18\/79 (23%) eyes at baseline and in 63\/79 (80%), 11\/79 (14%) and 5\/79 (6%) eyes at final follow\u2010up, respectively (p\u00a0&lt;\u00a00.001). Significant <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> improvement (defined as improvement of \u22653 Snellen lines at final follow\u2010up compared to baseline) occurred in 12\/24 (50%) eyes treated with antibiotics compared with 14\/16 (88%) eyes treated with antibiotics and corticosteroids (p\u00a0=\u00a00.02). Multivariate logistic regression was suggestive of the same association (odds ratio 7.0; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u201337.7; p\u00a0=\u00a00.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Optic nerve head lesion is a common and unique manifestation of ocular <jats:styled-content style=\"fixed-case\">CSD<\/jats:styled-content>. Most patients improved and had final good <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>. Combined antibiotics and corticosteroid treatment was associated with a better visual outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13684","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T11:59:35Z","timestamp":1520251175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Cat\u2010scratch disease: ocular manifestations and treatment outcome"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-0286","authenticated-orcid":false,"given":"Zohar","family":"Habot\u2010Wilner","sequence":"first","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3887-6238","authenticated-orcid":false,"given":"Omer","family":"Trivizki","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaella","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Kesler","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiri","family":"Shulman","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josepha","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Carmel Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-4254","authenticated-orcid":false,"given":"Radgonde","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hadassah Medical Center The Hebrew University Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"David","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hadassah Medical Center The Hebrew University Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Ben\u2010Arie\u2010Weintrob","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rambam Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Bakshi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Assaf Harofeh Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehoshua","family":"Almog","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Meir Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Sartani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Haemek Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicktoria","family":"Vishnevskia\u2010Dai","sequence":"additional","affiliation":[{"name":"The Goldschleger Eye Institute Department of Ophthalmology Sheba Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-2776","authenticated-orcid":false,"given":"Michal","family":"Kramer","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology Rabin Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Wolfson Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat","family":"Kehat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Bnai Zion Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Ephros","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit Carmel Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Giladi","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit and The Bernard Pridan Laboratory for Molecular Biology of Infectious Diseases Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1128\/jcm.35.8.1924-1930.1997","article-title":"Molecular diagnosis of cat scratch disease: a two\u2010step approach","volume":"35","author":"Avidor B","year":"1997","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_3_1","first-page":"172","article-title":"Optic neuritis in cat scratch disease","volume":"6","author":"Brazis PW","year":"1986","journal-title":"J Clin Neuroophthalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.042"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100100059029"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00573-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160766021"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-010-9389-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.58.030603.123700"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12932"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080150021012"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/B978-1-4557-4801-3.00236-8","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Gandhi TN","year":"2015"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(98)00038-1"},{"key":"e_1_2_5_14_1","first-page":"1078","volume-title":"Harrison's principles of internal medicine","author":"Giladi M","year":"2015"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/324162"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72893-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00784-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.125"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.83.12.1707"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1395-3907.2003.0080.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/523587"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12489"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2210.160115"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199906000-00010"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)96003-1"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273940801899780"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)93028-7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.1921-1933.2004"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1704.100825"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72125-7"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90452-9"},{"key":"e_1_2_5_33_1","first-page":"1380","article-title":"Optic neuritis and compressive neuropathy associated with cat scratch disease","volume":"103","author":"Sweeney VP","year":"1970","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31979-7"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199919040-00020"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0b013e31818d10d5"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.352"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:33:21Z","timestamp":1695040401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/aos.13684"],"URL":"https:\/\/doi.org\/10.1111\/aos.13684","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]},"assertion":[{"value":"2017-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}