{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:43:27Z","timestamp":1740149007915,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the change in peripheral perfusion status in patients with retinal vein occlusion (<jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>) during dexamethasone treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five eyes of patients with macular oedema due to either branch or central retinal vein occlusion were included. At baseline, patients were treated with an intravitreal dexamethasone implant (Ozurdex<jats:sup>\u00ae<\/jats:sup>) and followed until month 6. Wide\u2010field angiographies were classified as ischaemic and nonischaemic. Peripheral nonperfusion (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) was determined manually by calculating the percentage of nonperfusion area in relation to the total visible retina (ischaemic index).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen eyes showed evidence of &gt;10 disc area of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> at baseline and were graded as ischaemic <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>. In nonischaemic eyes, the mean area of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> was 0.3% at baseline, 0.6% after 1\u00a0month, 0.6% after 3\u00a0months and 0.6% after 6\u00a0months, respectively (p\u00a0&gt;\u00a00.05). In ischaemic <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>, the ischaemic index was calculated to be 18% at baseline. One month after treatment, mean area of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> was 16% and after 3\u00a0months was 19% (p\u00a0=\u00a00.8; p\u00a0=\u00a00.6). After retreatment, total <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> area was 18% (month 6; p\u00a0=\u00a00.9). During treatment, best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) increased and central retinal thickness (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) decreased from baseline to final follow\u2010up with no differences between nonischaemic\/ischaemic <jats:styled-content style=\"fixed-case\">RVO<\/jats:styled-content>. A significant negative correlation between the total area of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> and visual acuity was identified (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.6; p\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using 200\u00b0 wide\u2010field fluorescein angiography, the ischaemic index was shown to remain stable during dexamethasone treatment. This finding was consistent in ischaemic as well as in nonischaemic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13691","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T11:04:17Z","timestamp":1519729457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extension of peripheral nonperfusion in eyes with retinal vein occlusion during intravitreal dexamethasone treatment"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-7129","authenticated-orcid":false,"given":"Sandra","family":"Rezar\u2010Dreindl","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Medical University of Vienna Vienna 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