{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:14Z","timestamp":1792098554873,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To report on the efficacy and safety of CO<jats:sub>2<\/jats:sub> laser\u2010assisted sclerectomy surgery (CLASS) compared with trabeculectomy in primary open\u2010angle glaucoma and exfoliative glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirty\u2010one patients underwent <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content> (66 patients) or trabeculectomy (65 patients) and were followed up for 12\u00a0months. \u2018Complete success\u2019 was defined as intraocular pressure (IOP) between 10 and 18\u00a0mmHg and reduced by at least 30% from the baseline without medications, while \u2018qualified success\u2019 was compliant with the above criteria with or without the medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content> with trabeculectomy at 1\u00a0year, the mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction rate was 32.6\u00a0\u00b1\u00a010.8% versus 40.6\u00a0\u00b1\u00a015.9% (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and the average use of medications was 1.4\u00a0\u00b1\u00a01.4 versus 0.7\u00a0\u00b1\u00a01.1 (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). At 12\u00a0months, the complete success rate was 35% for <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content> versus 60% for trabeculectomy (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01), while the qualified success rate was 74% versus 75%, respectively, with no significant difference in qualified success rate between the groups at any time\u2010point (p<jats:italic>\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). Compared with <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content>, patients after trabeculectomy developed a higher rate of early complications (9.1% versus 29.2%, p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004), higher endothelial cell density (ECD) loss (1.4\u00a0\u00b1\u00a01.4% versus 6.5\u00a0\u00b1\u00a04.8%, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), higher astigmatism (0.0\u00a0\u00b1\u00a00.1 versus 0.1\u00a0\u00b1\u00a00.2, p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and significant visual acuity deterioration (0.1\u00a0\u00b1\u00a00.1; range 0\u20132 lines versus 0.4\u00a0\u00b1\u00a00.6; range 0\u20133 lines, p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content> shows a less potent hypotensive effect, it is similar to trabeculectomy in the qualified success rate and offers the reduction in medications up to 12\u00a0months. With a more attractive complications profile, <jats:styled-content style=\"fixed-case\">CLASS<\/jats:styled-content> may be an alternative to trabeculectomy, especially at the earlier glaucoma stage and in patients with a low ECD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13718","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T23:40:23Z","timestamp":1523749223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>CO<\/scp><sub>2<\/sub> laser\u2010assisted sclerectomy surgery compared with trabeculectomy in primary open\u2010angle glaucoma and exfoliative glaucoma. A 1\u2010year follow\u2010up"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-5434","authenticated-orcid":false,"given":"Judyta","family":"Jankowska\u2010Szmul","sequence":"first","affiliation":[{"name":"Department of Ophthalmology School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Dobrowolski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Wylegala","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200011000-00002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.188399"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701403"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3180391a04"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-006-0413-4"},{"key":"e_1_2_5_7_1","first-page":"779","article-title":"Central corneal endothelial cell changes over a ten\u2010year period","volume":"38","author":"Bourne WM","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91288-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000243473.59084.dd"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050127"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2001.60"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000137869.18156.81"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.05.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.12.1354"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700148"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.11.055"},{"key":"e_1_2_5_17_1","first-page":"130","article-title":"European glaucoma society terminology and guidelines for glaucoma, 4th edition \u2010 chapter 3: treatment principles and options. Supported by the EGS Foundation","volume":"101","author":"EGS","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00263-3"},{"key":"e_1_2_5_19_1","first-page":"CD007059","article-title":"Non\u2010penetrating filtration surgery versus trabeculectomy for open\u2010angle glaucoma","author":"Eldaly MA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_20_1","first-page":"52","article-title":"Non penetrating deep sclerectomy in open angle glaucoma","volume":"3","author":"Fyodorov SN","year":"1989","journal-title":"Eye Microsurg"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199705000-00010"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.07.022"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181f7b14f"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000187"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13372"},{"key":"e_1_2_5_26_1","article-title":"Long\u2010term results of deep sclerectomy in normal\u2010tension glaucoma","author":"Harju M","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328325a54b"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31814b98f7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.1.6"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334776"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.049"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112622"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.02.028"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.043"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.140"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200004000-00015"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1170-5"},{"key":"e_1_2_5_38_1","first-page":"333","article-title":"A comparative study of human corneal keratocyte and endothelial cell density during aging","volume":"16","author":"Moller\u2010Pedersen T","year":"1997","journal-title":"Cornea"},{"key":"e_1_2_5_39_1","unstructured":"R Core Team(2017):R: A language and environment for statistical computing.Vienna Austria:R Foundation for Statistical Computing. Available at:https:\/\/www.R-project.org\/. (Accessed on 19 Jul 2017)."},{"key":"e_1_2_5_40_1","first-page":"395","article-title":"The effect of trabeculectomy on corneal topography","volume":"23","author":"Rosen WJ","year":"1992","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328091c1ae"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.10.035"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3182707406"},{"key":"e_1_2_5_44_1","first-page":"251","article-title":"The effect of glaucoma filtering surgery on corneal endothelial cell density","volume":"22","author":"Smith DL","year":"1991","journal-title":"Ophthalmic Surg"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.018"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181659e56"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02831.x"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13161"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13288"},{"key":"e_1_2_5_50_1","first-page":"135","article-title":"CO2 laser\u2010assisted sclerectomy surgery. Part I: concept and experimental models","volume":"21","author":"Ton Y","year":"2012","journal-title":"J Glaucoma"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15659"},{"key":"e_1_2_5_52_1","first-page":"199","article-title":"Trabeculectomy: a modified ab externo technique","volume":"2","author":"Watson P","year":"1970","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000386"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005294"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:10:22Z","timestamp":1694995822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,14]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/aos.13718"],"URL":"https:\/\/doi.org\/10.1111\/aos.13718","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,14]]},"assertion":[{"value":"2017-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}