{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T09:50:35Z","timestamp":1792317035302,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>We describe eight patients with juvenile idiopathic arthritis\u2010related chronic uveitis, who received a fluocinolone acetonide implant (FAI<\/jats:styled-content>, Retisert\u00ae, Bausch&Lomb) in one eye. All patients had poor visual acuity (VA) due to persistent macular oedema in one or both eyes despite treatment with antirheumatic medication.<\/jats:p><\/jats:sec>Methods<\/jats:title>Median age of the patients was 22.9\u00a0years (range, 14.1\u201339.7) and duration of uveitis 13.0\u00a0years (range, 6.8\u201328.4) at FAI<\/jats:styled-content> implantation. Median preoperative best\u2010corrected visual acuity (BCVA<\/jats:styled-content>) was 0.1 (range, 0.05\u20130.4) and Standardization of Uveitis Nomenclature, SUN<\/jats:styled-content>\u2010grade was SUN<\/jats:styled-content> 2+ (range, 0.5\u20134.0). All patients had been treated extensively with systemic corticosteroids and antirheumatic drugs by the time of FAI<\/jats:styled-content> implantation. The median follow\u2010up time was 5.3\u00a0years (range, 4.4\u20136.3).<\/jats:p><\/jats:sec>Results<\/jats:title>Macular edema resolved in a median time of 0.2\u00a0years (range, 0.04\u20130.39) after the FAI<\/jats:styled-content> implantation. The median BCVA<\/jats:styled-content> was 0.5\u20130.63 (range, 0.1\u20131.0) from 1 to 5\u00a0years of follow\u2010up. Macular edema did not recur in 5 eyes after the implantation. In three eyes, the macular oedema relapsed at 2.7, 2.9 and 5.5 years of follow\u2010up. All our patients needed antirheumatic drugs in addition to the FAI<\/jats:styled-content> to treat their macular edema. During the follow\u2010up, 7 eyes required further intraocular operations: 4 cataract operations, 4 intraocular pressure \u2010lowering operations and 1 retinal detachment surgery were performed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Fluocinolone acetonide implant is a valuable option in the treatment of persistent macular edema associated with JIA<\/jats:styled-content>\u2010related uveitis refractory to systemic treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13744","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T23:47:30Z","timestamp":1523749650000},"page":"648-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fluocinolone acetonide intravitreal implant (Retisert\u00ae<\/sup>) in the treatment of sight threatening macular oedema of juvenile idiopathic arthritis\u2010related uveitis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-9890","authenticated-orcid":false,"given":"Sanna","family":"Leinonen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Immonen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-3894","authenticated-orcid":false,"given":"Kaisu","family":"Kotaniemi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Helsinki University Hospital Helsinki 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