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They may develop as by\u2010products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      have visual field defects. Optic disc drusen (ODD)\u2010associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      . In children, the\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high\u2010resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      . This allows for\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      was conducted using the\n                      <jats:styled-content style=\"fixed-case\">PUBMED<\/jats:styled-content>\n                      database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease\u2010tracking methodologies, structure\u2013function relationships and treatment strategies of\n                      <jats:styled-content style=\"fixed-case\">ODD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13748","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:59:25Z","timestamp":1523879965000},"page":"673-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Optic disc drusen: understanding an old problem from a new perspective"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-2716","authenticated-orcid":false,"given":"Steffen","family":"Hamann","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet University of Copenhagen Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Malmqvist","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet University of Copenhagen Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00708-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1988.66"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00357-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.149136"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2016.1198917"},{"key":"e_1_2_8_7_1","first-page":"331","article-title":"[Autofluorescence of papillary drusen in the diagnosis of false papillary edema]","volume":"76","author":"Bonnin P","year":"1976","journal-title":"Bull Soc Ophtalmol Fr"},{"key":"e_1_2_8_8_1","first-page":"243","article-title":"Drusen of the optic disc and occipital transient pattern reversal responses. 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