{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:28:50Z","timestamp":1756636130468,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POPV 2007\u20102013"],"award-info":[{"award-number":["POPV 2007\u20102013"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the supraciliary versus intrascleral implantation of the hema implant (Esnoper V\u20102000) in terms of the efficacy and safety in nonpenetrating deep sclerectomy (<jats:styled-content style=\"fixed-case\">NPDS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Prospective, randomized, unmasked, competitive and multicenter clinical trial. Eighty\u2010three eyes from 83 patients suffering from open\u2010angle glaucoma (40 males, 43 females) were enrolled and followed up for 12\u00a0months. Main outcome measures were best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>), intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>), perimetry (mean defect, <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> and Visual Field Index, <jats:styled-content style=\"fixed-case\">VFI<\/jats:styled-content>), pachymetry, number of antiglaucoma medications and analysis of blebs according Moorfields Bleb Grading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was significantly reduced in both groups from 23.74\u00a0\u00b1 6.9\u00a0mmHg (implant sutured to the sclera, group 1) and 23.46\u00a0\u00b1\u00a06.47\u00a0mmHg (implant placed in the suprachoroidal space, group 2) to 15.43\u00a0\u00b1\u00a04.27\u00a0mmHg (p\u00a0&lt;\u00a00.001) and 14.62\u00a0\u00b1\u00a03.64\u00a0mmHg (p\u00a0&lt;\u00a00.001), respectively. There were no statistically significant differences in mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> values between the groups a year after the surgery (p\u00a0=\u00a00.581). <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content> did not show statistical differences in comparison with baseline (p\u00a0=\u00a00.09, group 1; p\u00a0=\u00a00.42, group 2). The mean number of antiglaucoma medications was reduced in both groups from 2.58\u00a0\u00b1\u00a00.04 and 2.68\u00a0\u00b1\u00a00.02 before the surgery to 0.32\u00a0\u00b1\u00a00.76 and 0.24\u00a0\u00b1\u00a00.66 after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nonpenetrating deep sclerectomy using hema implant (Esnoper V\u20102000) is safe and effective regardless of the positioning of the implant. We achieved <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> decrease and reduction in antiglaucoma medications during the first year after surgery without significant differences between both techniques.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13749","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T03:09:14Z","timestamp":1527822554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Supraciliary versus intrascleral implantation with hema implant (Esnoper V\u20102000) in deep sclerectomy: a multicenter randomized controlled trial"],"prefix":"10.1111","volume":"96","author":[{"given":"Jose I.","family":"Belda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Torrevieja Hospital Alicante 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