{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:41:40Z","timestamp":1790419300619,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The objective of this study was to investigate the relationship between visual acuity, peripapillary retinal nerve fibre layer (pRNFL), retinal thickness at the fovea and other factors with the neurologic status of former preterm children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional hospital based study in a maximum care tertiary centre, detailed anthropometric and ophthalmological data of former preterm children ranging from 4 to 10\u00a0years of age with a gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) \u226432\u00a0weeks were assessed. Analyses of the correlation between <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> and foveal thickness, as well as visual acuity (VA) parameters at 4\u201310\u00a0years of age, with neurological development were evaluated at 2\u00a0years of age by Bayley Scales <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> of Infant Development, including Psychomotor Developmental Index (<jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content>) and Mental Developmental Index (<jats:styled-content style=\"fixed-case\">MDI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available for 106 former preterm children. Univariate analysis revealed a correlation between <jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> thickness (<jats:italic>B<\/jats:italic>\u00a0=\u00a00.43; p\u00a0=\u00a00.013), VA (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u221229.2; p\u00a0&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:italic>B<\/jats:italic>\u00a0=\u00a02.7; p\u00a0=\u00a00.002), retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>;<jats:italic> B<\/jats:italic>\u00a0=\u00a0\u221216.3; p\u00a0&lt;\u00a00.001) and intraventricular haemorrhages (<jats:styled-content style=\"fixed-case\">IVH<\/jats:styled-content>;<jats:italic> B<\/jats:italic>\u00a0=\u00a0\u221222.9; p\u00a0&lt;\u00a00.001) but not with strabismus or foveal thickness. In the multivariable analysis, the association remained for visual acuity and <jats:styled-content style=\"fixed-case\">IVH<\/jats:styled-content>, but not for <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> thickness or <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. Mental Developmental Index (<jats:styled-content style=\"fixed-case\">MDI<\/jats:styled-content>) was associated with visual acuity (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u221234.3; p\u00a0=\u00a00.001), <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> (<jats:italic>B<\/jats:italic>\u00a0=\u00a02.53; p\u00a0=\u00a00.02) and <jats:styled-content style=\"fixed-case\">IVH<\/jats:styled-content> (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u221215.4; p\u00a0=\u00a00.02), the latter also in the multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed an association between <jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content> at 2\u00a0years of age and lower visual acuity later in childhood. However, there was no correlation between retinal morphology and neurologic outcome in former preterm children after adjusting for several potential confounders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13755","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T04:56:40Z","timestamp":1520657800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4\u201310\u00a0years"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-2350","authenticated-orcid":false,"given":"Achim","family":"Fie\u00df","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Helios Dr. Horst Schmidt Klinik Wiesbaden Germany"},{"name":"Department of Ophthalmology University Medical Centre Mainz Mainz 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