{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:21:10Z","timestamp":1779337270080,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Posterior capsule opacification (PCO) occurs as a common complication after cataract surgery. Erlotinib is an inhibitor of the epidermal growth factor\u2013Receptor and reduces critical cellular events leading to <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>. In this <jats:italic>in\u00a0vitro<\/jats:italic> study, Erlotinib\u2010modified intraocular lenses (<jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>s) employed as a drug delivery device have been evaluated for <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content> prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> concentration of Erlotinib was determined by using FHL\u2010124 cells. For the human capsular bag model, 40 cadaver eyes underwent sham cataract surgery. Sixteen capsular bags were exposed to the <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> of Erlotinib. Intraocular lens (IOL) of three different materials was pharmacologically modified and tested in the anterior segment model and implanted into 24 capsular bags. To test for corneal toxicity, pairs of human cornea were exposed to high concentrations of Erlotinib and corneal endothelial cells (CEC) were exposed to the modified <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>. Release kinetics of Erlotinib from the <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content> was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> of Erlotinib was determined to be 10\u00a0<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>. Erlotinib alone (p\u00a0=\u00a00.002) and when soaked into <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>s (p\u00a0&lt;\u00a00.001) significantly increased the number of days needed until total cell coverage of the capsular bags in comparison with the control. Modified <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>s mitigated cell growth in the anterior segment model (p\u00a0&lt;\u00a00.001). No short\u2010term corneal toxicity was observed up to a concentration of 100\u00a0<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>, and <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>s did not show toxicity on CEC. Erlotinib was released constantly from <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Erlotinib might be of clinical relevance in <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content> prophylaxis, as its short\u2010term application induces a long\u2010term deceleration of cellular growth. Erlotinib can be introduced into the eye via soaked <jats:styled-content style=\"fixed-case\">IOL<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13759","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T03:10:53Z","timestamp":1527822653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The intraocular lens as a drug delivery device for an epidermal growth factor\u2013Receptor inhibitor for prophylaxis of posterior capsule opacification"],"prefix":"10.1111","volume":"96","author":[{"given":"Christian","family":"Wertheimer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ludwig\u2010Maximilians\u2010University Munich 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