{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:56:10Z","timestamp":1788285370898,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To characterize ocular manifestations in a cohort of paediatric patients with incontinentia pigmenti (\n                      <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                      ) and to define the guidelines for grading of\n                      <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                      \u2010associated retinopathy (\n                      <jats:styled-content style=\"fixed-case\">IPR<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective review was performed on patients under the age of 18\u00a0years with a diagnosis of\n                      <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                      . Data included demographics, medical history, ocular examination, and accessory examination. Ocular and systemic physical examinations of the parents were carried out to determine the familial history.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010one children (58 females and three males) with median age of 3.7\u00a0months were observed consecutively. The median follow\u2010up duration was 13.4\u00a0months (range: 6.5\u201375.0\u00a0months). A total of 47 patients had various ocular anomalies. Among them, 28 patients had bilateral ocular anomalies and 19 had unilateral anomalies. Vitreoretinal changes were noted in 73 of 122 eyes, including eight eyes with retinal pigment epithelium changes only (Stage 1), 22 eyes with retinal vascular abnormalities (Stage 2), five eyes with epiretinal membranes or fibrotic hyperplasia combined with avascularized zones (Stage 3), six eyes with retinal neovascularization (Stage 3), one eye with vitreous haemorrhage (Stage 3), 10 eyes with partial retinal detachment (\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      ) (Stage 4a), 15 eyes with total\n                      <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>\n                      (Stage 4b) and eight eyes with phthisis bulbi and secondary glaucoma (Stage 5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Various vitreoretinal manifestations can be found in paediatric patients with\n                      <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                      and classified into five stages, which are characterized by retinal vasculopathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.13781","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:44:18Z","timestamp":1533602658000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Incontinentia pigmenti\u2010associated ocular anomalies of paediatric incontinentia pigmenti patients in China"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-3682","authenticated-orcid":false,"given":"Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Xin Hua Hospital School of Medicine Shanghai Jiao Tong 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