{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:51:24Z","timestamp":1777906284170,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010064","name":"Fonds Voor Research In Oftalmologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010064","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To obtain insights on the protein composition of posterior capsular plaques (<jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content>) in congenital unilateral cataract with anterior vitreolenticular interface dysgenesis (<jats:styled-content style=\"fixed-case\">AVLID<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Posterior capsular plaque's were collected during surgery in children presenting with congenital unilateral cataract. Surgeries were analysed focusing on the type of cataract, the integrity of the posterior capsule after peeling the <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> and the presence of vitreolenticular adherences when performing primary posterior capsulorhexis. Proteome analysis was performed on the collected <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Posterior capsular plaques collection and proteome analysis were feasible from four children presenting with unilateral idiopathic congenital cataract and <jats:styled-content style=\"fixed-case\">AVLID<\/jats:styled-content>. A large portion of the proteins found in the <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content>s was similar to the proteins known to be present in lens epithelial cells and fibres. Proteins like vimentin, fibronectin, collagen type I, collagen type <jats:styled-content style=\"fixed-case\">VI<\/jats:styled-content> and lumican were also found, which typically are present in mesenchymal tissue but not in lens tissue or capsule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Posterior capsular plaques in cases of unilateral idiopathic congenital cataract of the <jats:styled-content style=\"fixed-case\">AVLID<\/jats:styled-content> type present a protein composition of mainly proteins found in lens epithelial cells and fibres. Some proteins however are a specific for lens tissue and are typically seen in mesenchymal tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13782","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T08:01:23Z","timestamp":1538553683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proteomic analysis of posterior capsular plaques in congenital unilateral cataract"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-3516","authenticated-orcid":false,"given":"Jan","family":"Van Looveren","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Antwerp University Hospital Edegem Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Van Gerwen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Schildermans","sequence":"additional","affiliation":[{"name":"Centre for Proteomics University of Antwerp Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris","family":"Laukens","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Baggerman","sequence":"additional","affiliation":[{"name":"Centre for Proteomics University of Antwerp Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Jos\u00e9","family":"Tassignon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Antwerp University Hospital Edegem Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.03.033"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.08.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2006.00370.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.06.024"},{"key":"e_1_2_7_6_1","first-page":"3","article-title":"Transforming Growth Factor\u2010\u03b2\u2010Induced Epithelial\u2010Mesenchymal Transition in the Lens: a Model for Cataract Formation","volume":"4","author":"Iongh RU","year":"2005","journal-title":"Cells Tissues Organs 179(1\u20102):"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13497"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.07.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.07.015"},{"key":"e_1_2_7_10_1","first-page":"2108","article-title":"Congenital and infantile cataract in the United Kingdom: underlying or associated factors","volume":"41","author":"Rahi JS","year":"2000","journal-title":"British Congenital Cataract Interest Group. 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