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Other assessments included blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) profiles, blood glucose and lipid metabolism markers, Framingham risk scores (<jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>), carotid intima\u2010media thickness (c\u2010<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) and brachial flow\u2010mediated dilation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Family history\u2010positive subjects showed decreased retinal arterial baseline diameter fluctuation, dilation amplitude, percent dilation, and overall constriction response slope (p\u00a0=\u00a00.001; p\u00a0=\u00a00.015; p\u00a0=\u00a00.001; and p\u00a0&lt;\u00a00.001, respectively) and increased percent constriction (p\u00a0=\u00a00.008). On the venous side, baseline\u2010corrected flicker response and dilation response slope were decreased in the<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u2010positive group (p\u00a0=\u00a00.009 and p\u00a0=\u00a00.010, respectively). There were no significant differences between groups in c\u2010<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>scores or<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>parameters (all p\u00a0&gt;\u00a00.05). The arterial<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>% correlated negatively with decreased high\u2010density lipoprotein cholesterol (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u22120.52, p\u00a0=\u00a00.002) in only<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u2010positive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although macrovascular function is preserved in individuals with<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>positive for<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>but with low<jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>, there are, however, functional impairments at the retinal microvascular level that correlate with established plasma markers for cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13783","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T01:54:20Z","timestamp":1536544460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Retinal vascular function in asymptomatic individuals with a positive family history of cardiovascular disease"],"prefix":"10.1111","volume":"96","author":[{"given":"Swathi","family":"Seshadri","sequence":"first","affiliation":[{"name":"Vascular Research Laboratory School of Life and Health Sciences Aston University Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said E.","family":"Karimzad","sequence":"additional","affiliation":[{"name":"Vascular Research Laboratory School of Life and Health Sciences Aston University Birmingham 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