{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:37:24Z","timestamp":1782779844862,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790641"],"award-info":[{"award-number":["81790641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health and Family Planning Commission of the People's Republic of China","doi-asserted-by":"publisher","award":["201302015"],"award-info":[{"award-number":["201302015"]}],"id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open\u2010angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, cross\u2010sectional, case\u2013control study was conducted in 163 POAG patients and 103 normal controls. Clinical and demographic information was obtained from the medical data platform of the Eye &amp; ENT Hospital of Fudan University, Shanghai, China. The POAG patients were categorised into mild [median deviation (MD)\u00a0\u2264\u00a06.00\u00a0dB], moderate (MD\u00a0&gt;\u00a06 Db\u2013\u226512\u00a0dB) and severe (MD\u00a0&gt;\u00a012\u00a0dB) subgroups, based on their visual field MD results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of serum UA in the POAG group (0.321\u00a0\u00b1\u00a00.084\u00a0mmol\/l) was approximately 12.77% lower (p\u00a0&lt;\u00a00.001) than that of the control group (0.362\u00a0\u00b1\u00a00.053\u00a0mmol\/l). The UA\/creatinine (Cr) ratio was approximately 14.99% lower (p\u00a0&lt;\u00a00.001) in patients with POAG (4.47\u00a0\u00b1\u00a01.15), compared with the control group (5.14\u00a0\u00b1\u00a01.05). The mean level of UA was lowest in the severe POAG group, followed by the moderate POAG group, and the mild POAG group (p\u00a0&lt;\u00a00.001). A similar trend was observed when UA levels were compared between the POAG and control groups in males. Multivariate regression analyses showed a significant negative correlation between UA and vertical cup\u2013disc ratio (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22120.320, p\u00a0=\u00a00.034), and UA and MD (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22120.441, p\u00a0=\u00a00.031) in males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary open\u2010angle glaucoma patients have lower UA levels; however, a negative association between UA levels and disease severity was evident in male patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13789","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T16:02:42Z","timestamp":1524153762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Association of serum uric acid levels with primary open\u2010angle glaucoma: a 5\u2010year case\u2013control study"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-740X","authenticated-orcid":false,"given":"Shengjie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhui","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Genes Related to Diseases Ministry of Education Medical School Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Ophthalmology &amp; Visual Science Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Science Eye &amp; ENT Hospital, Shanghai Medical College Fudan University Shanghai China"},{"name":"State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science Fudan University Shanghai China"},{"name":"Key Laboratory of Myopia Ministry of Health (Fudan 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