{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:21:24Z","timestamp":1788315684823,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010816","name":"Stiftelsen f\u00f6r Synskadade i f.d. 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Intraocular pressure reduction was analysed 1\u00a0month after initiation of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighteen patients (143 eyes) received mono\u2010therapy and 122 patients (152 eyes) multi\u2010therapy. Median baseline <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was 24.0 (min: 9.7, max: 56.0) mmHg in mono\u2010therapy eyes and 24.0 (min: 12.3, max: 48.5) mmHg in multi\u2010therapy eyes (p\u00a0=\u00a00.56). After 1\u00a0month in the two groups, respectively, values for median <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction were 6.3 (range: \u22125.3\u201331.0) and 11.0 (range: 0.7\u201334.5) mmHg, and for mean relative decline 26.8 (range: \u221232.0\u201355.4) and 46.0 (range: 4.6\u201381.6) % (p\u00a0=\u00a00.000). A larger proportion of the multi\u2010therapy patients reached each target <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> level (p\u00a0=\u00a00.000). The higher the baseline <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>, the larger the observed pressure reduction, considering both absolute and relative figures. The effect was more pronounced in eyes with multi\u2010therapy than in those with mono\u2010therapy (p\u00a0=\u00a00.000). For every mmHg higher <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> at baseline, the <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was reduced by an additional 0.56 (mono\u2010therapy) or 0.84 (multi\u2010therapy) mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensive treatment led to considerably greater <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction than mono\u2010therapy. Among patients with <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> \u226530\u00a0mmHg at diagnosis an <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> of &lt;16 was reached in 2\/3 of those with multi\u2010therapy but in none with mono\u2010therapy. The <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> reduction was highly dependent on the untreated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13790","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T12:42:14Z","timestamp":1537620134000},"page":"567-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Initial intraocular pressure reduction by mono\u2010 versus multi\u2010therapy in patients with open\u2010angle glaucoma: results from the Glaucoma Intensive Treatment Study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-4740","authenticated-orcid":false,"given":"Christina","family":"Lind\u00e9n","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Ophthalmology Ume\u00e5 University Ume\u00e5 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