{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:33:12Z","timestamp":1793853192546,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Optic nerve head (<jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content>) parameters as well as circumpapillary retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content>) thickness values measured with two different spectral domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) machines (Spectralis<jats:sup>\u00ae<\/jats:sup> and Cirrus<jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) have been compared between two patient groups, primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>), nonarteritic anterior ischaemic optic neuropathy (<jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content>) and healthy controls. A comparison of the performance of the two <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> machines was made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy controls, 20 <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> and 20 <jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content> patients with comparable visual field defects were included. Comparison between groups was made using <jats:sc>anova<\/jats:sc> and post hoc <jats:italic>t<\/jats:italic>\u2010tests. To evaluate the diagnostic power of <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> to differentiate <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content>, a stepwise linear regression analysis of the rim\u2010<jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> correlation with adjusting covariates (optic disc area and age) was performed. Based on the regression formula, the area under the receiver operator characteristic (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both glaucoma and <jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content> patients showed significantly smaller global <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness values compared to healthy subjects in <jats:italic>t<\/jats:italic>\u2010tests (p\u00a0&lt;\u00a00.001), while only patients with glaucoma showed significantly smaller global <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> parameters for both devices compared to healthy subjects (p\u00a0&lt;\u00a00.001). Correlation between global <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> parameters was highly statistically significant (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.93), whereas in <jats:italic>t<\/jats:italic>\u2010test a statistically significant difference between the two machines was detected (p\u00a0&lt;\u00a00.001). Area under the receiver operator characteristic revealed a similarly good discrimination between glaucoma and <jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content> for Spectralis<jats:sup>\u00ae<\/jats:sup> (0.980) and Cirrus<jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (0.945).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content> patients have similar <jats:styled-content style=\"fixed-case\">RNFL<\/jats:styled-content> thickness values as do glaucomatous eyes, whereas <jats:styled-content style=\"fixed-case\">ONH<\/jats:styled-content> parameters in <jats:styled-content style=\"fixed-case\">NAION<\/jats:styled-content> eyes were similar to those seen in healthy controls. This difference might help discriminating between these two different disease conditions in a chronic disease stadium, and in this regard, none of the two <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> machines performed better.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13804","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:59:56Z","timestamp":1537581596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Optic nerve head morphology in primary open\u2010angle glaucoma and nonarteritic anterior ischaemic optic neuropathy measured with spectral domain optical coherence tomography"],"prefix":"10.1111","volume":"96","author":[{"given":"Hemma","family":"Resch","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University Vienna Vienna 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