{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:42:24Z","timestamp":1776339744942,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study peripapillary choroidal thickness (<jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content>) around the optic disc and establish zones using a new swept source optical coherence tomography (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) device. To evaluate <jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content> differences between patients with multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) and age\u2010 and sex\u2010matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 102 healthy subjects and 51 patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> were consecutively recruited. Healthy subjects were divided into teaching (<jats:italic>n<\/jats:italic>\u00a0=\u00a051, used to establish choroidal zones) and validating (<jats:italic>n<\/jats:italic>\u00a0=\u00a051, used to compare measurements with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> patients) populations. An optic disc 6.0\u00a0\u00d7\u00a06.0\u2010mm three\u2010dimensional scan was obtained using <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> Triton. A 26\u00a0\u00d7\u00a026 cube\u2010grid centred on the optic disc was generated automatically to measure <jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content>. Four choroidal zones were established and used to compare <jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content> between healthy controls and patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peripapillary choroidal thickness (<jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content>) was significantly thinner in patients in all concentric zones (p\u00a0\u2264\u00a00.0001): 134.02\u00a0\u00b1\u00a016.59\u00a0<jats:italic>\u03bc<\/jats:italic>m in <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group versus 171.56\u00a0\u00b1\u00a012.43\u00a0<jats:italic>\u03bc<\/jats:italic>m in the control group in zone 2; 182.23\u00a0\u00b1\u00a020.52 versus 219.03\u00a0\u00b1\u00a017.99\u00a0<jats:italic>\u03bc<\/jats:italic>m, respectively, in zone 3; and 223.52\u00a0\u00b1\u00a010.70 versus 259.99\u00a0\u00b1\u00a010.29\u00a0<jats:italic>\u03bc<\/jats:italic>m, respectively, in zone 4. The choroidal thinning in the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group tended to decrease as we distanced from the optic nerve head. Peripapillary choroidal thickness (<jats:styled-content style=\"fixed-case\">PPCT<\/jats:styled-content>) had a similar pattern in controls and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>; it was thicker in the superior region, followed by temporal, nasal and inferior regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> showed peripapillary choroidal thinning when compared with healthy subjects in all zones around the optic disc. Peripapillary choroidal tissue shows a concentric pattern, increasing in thickness when increasing the distance from the optic nerve. The new <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> could be useful for evaluating choroidal thinning in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13807","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:20:08Z","timestamp":1537575608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Changes in peripapillary choroidal thickness in patients with multiple sclerosis"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6258-2489","authenticated-orcid":false,"given":"Elena","family":"Garcia\u2010Martin","sequence":"first","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Jarauta","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"},{"name":"Neurology Department Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Pablo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria P.","family":"Bambo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose R.","family":"Ara","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"},{"name":"Neurology Department Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Martin","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"},{"name":"Neurology Department Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Polo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Larrosa","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Vilades","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"},{"name":"Anatomic Pathology Department Lozano Blesa University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-5994","authenticated-orcid":false,"given":"Maria","family":"Satue","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Miguel Servet University Hospital Zaragoza Spain"},{"name":"Aragon Institute for Health Research (IIS Arag\u00f3n) University of Zaragoza Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12962"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.02.034"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10483"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32835d9245"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2000.tb04912.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7364"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8771"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018132"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bp010040m"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.01.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441152"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.010"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.029"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000123"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510397414"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318299ccd9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-12-29"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3325"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16521"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.07.011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00068-5"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.016"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.11.008"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-8159-4"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13257"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_5_31_1","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan RS","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.371"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2017.1370116"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.032"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(02)00022-6"},{"key":"e_1_2_5_36_1","article-title":"Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis \u2010 a pilot study","author":"Svr\u010dinov\u00e1 T","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8782"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.037"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-011-0048-9"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199702000-00006"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm291"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.06.005"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:37:07Z","timestamp":1694309827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/aos.13807"],"URL":"https:\/\/doi.org\/10.1111\/aos.13807","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]},"assertion":[{"value":"2017-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}