{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:07:15Z","timestamp":1781251635347,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T00:00:00Z","timestamp":1528502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002089","name":"Fight for Sight","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Acute infectious conjunctivitis is a common disease. While usually self\u2010limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0\u20134\u00a0years in Denmark, Norway and Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using individual\u2010level data from the Danish National Prescription Registry (2000\u20132015), we provided detailed descriptions of treatment patterns at the individual level, stratified by age (0\u20131\u00a0years, 2\u20134\u00a0years) and antibiotic substance. Aggregate\u2010level data for Danish, Norwegian and Swedish children (0\u20134\u00a0years) were obtained from publicly available data sources (2000\u20132016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 107\u00a0581 Danish children aged 0\u20134\u00a0years receiving 271\u00a0980 treatment episodes. The incidence rate was relatively stable between 2000 and 2010 (on average, 637 and 283\/1000 person\u2010years for 0\u2010 to 1\u2010 and 2\u2010 to 4\u2010year\u2010olds, respectively), after which it dropped by 37% until 2015. In the aggregated data, a markedly higher use was seen in Denmark (211\/1000 children in 2016) compared with Sweden (42) and Norway (151). The decrease from 2010 onwards was observed in all three countries. Chloramphenicol and fusidic acid were the most commonly used topical ocular antibiotics across Scandinavia. Tobramycin was rarely used in Norway and Sweden (\u22641\/1000 children in 2016) compared with Denmark (24\/1000 children).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considerable variation is seen in the utilization of topical ocular antibiotics among children in Scandinavia, with Denmark having the highest use. Across the Scandinavian countries, however, a decline was noted from 2010 onwards.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13813","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T22:04:32Z","timestamp":1528581872000},"page":"789-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-1791","authenticated-orcid":false,"given":"Jasmine","family":"Andersson","sequence":"first","affiliation":[{"name":"Lysningen Research Center Trekroner Denmark"},{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Hofsli","sequence":"additional","affiliation":[{"name":"Lysningen Research Center Trekroner Denmark"},{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe Lomholt","family":"Gade","sequence":"additional","affiliation":[{"name":"Lysningen Research Center Trekroner Denmark"},{"name":"Department of Medicine Holbaek Hospital Holbaek Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Heegaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet\u2010Glostrup Hospital Copenhagen Denmark"},{"name":"Department of Ophthalmology and Pathology Eye Pathology Section Rigshospitalet\u2010Glostrup Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Lysningen Research Center Trekroner Denmark"},{"name":"Clinical Pharmacology and Pharmacy Department of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2011.10.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280318"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.5778"},{"key":"e_1_2_5_5_1","unstructured":"Danish Health Authority(2013):Infectious diseases in children a guideline for institutions nurseries and parents. In Danish [Sundhedsstyrelsen. Smitsomme sygdomme hos b\u00f8rn vejledning for daginstitutioner skoler og for\u00e6ldre]. Available at:https:\/\/www.sst.dk\/da\/sygdom-og-behandling\/smitsomme-sygdomme\/~\/media\/6DD0337E233B4AD68DA33E313EE60A58.ashx. (Accessed on 13 Dec 2017)."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/19.6.658"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38891.551088.7C"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp16X686125"},{"key":"e_1_2_5_9_1","unstructured":"Guidelines for ATC classification and DDD assignment 2016. Oslo 2016(n.d.):"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01006.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813432.2014.972067"},{"key":"e_1_2_5_12_1","unstructured":"National Health Service(2018):Conjunctivitis. 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