{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:41:25Z","timestamp":1790854885801,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare results between standard and accelerated corneal collagen cross\u2010linking (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) for the treatment of progressive keratoconus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed literature searches in PubMed, Cochrane Library, Web of Science, <jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content> registry, ClinicalTrials.gov, and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> for studies comparing conventional Dresden (C\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) and accelerated <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> (A\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>). Outcomes were clinical results and changes in corneal properties. Weighted mean differences were used to evaluate the effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Here, 22\u00a0studies with 1158 eyes (C\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>: 577\u00a0eyes; A\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>: 581\u00a0eyes) were included. At the last follow\u2010up, C\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> was superior regarding minimum keratometry (p\u00a0&lt;\u00a00.00001) and demarcation line depth (p\u00a0&lt;\u00a00.00001), whereas A\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> should be favoured when considering minimum corneal thickness (p\u00a0=\u00a00.0005). No differences in uncorrected and corrected distance visual acuity (p\u00a0=\u00a00.09 and 0.98), spherical equivalent (p\u00a0=\u00a00.11), spherical and cylindrical error (p\u00a0=\u00a00.29 and 0.32), maximal and average keratometry (p\u00a0=\u00a00.05 and 0.65), central corneal thickness (p\u00a0=\u00a00.15), corneal biomechanical properties (p\u00a0\u2265\u00a00.21 respectively), time of reepithelialization (p\u00a0=\u00a00.76), subbasal nerve density (p\u00a0=\u00a00.69), endothelial cell density (p\u00a0=\u00a00.30) and morphology (p\u00a0\u2265\u00a00.40 respectively) were found among both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consideration of less corneal thinning favours A\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>, whereas the deeper demarcation line and greater changes in minimum keratometric values in C\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> may indicate a higher treatment efficacy. Altogether, C\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>, as well as A\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>, provides successful results in the strengthening of corneal tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13814","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T04:25:15Z","timestamp":1527827115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Comparison of standard and accelerated corneal cross\u2010linking for the treatment of keratoconus: a meta\u2010analysis"],"prefix":"10.1111","volume":"97","author":[{"given":"Mehdi","family":"Shajari","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Goethe\u2010University Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin 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