{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:27:46Z","timestamp":1785554866225,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the inflammation associated with the use of standard silicone oil (polydimethylsiloxane; PDMS) and heavy silicone oil (HSO) Densiron\u201068\u2122 in patients undergoing vitrectomy for retinal detachment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective study was performed involving 35 patients scheduled to undergo vitrectomy for retinal detachment. Patients received PDMS or Densiron\u201068\u2122 HSO according to superior or inferior retinal localization of the tears, respectively. For assessing the inflammation, prostaglandin E2 (PGE<jats:sub>2<\/jats:sub>) and interleukin\u20101<jats:italic>\u03b1<\/jats:italic> (IL\u20101<jats:italic>\u03b1<\/jats:italic>) levels were evaluated in the aqueous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five eyes of 35 patients completed the study: 20 eyes received HSO, and 15 eyes received PDMS. The mean aqueous PGE<jats:sub>2<\/jats:sub> level was significantly higher in HSO patients than in PDMS patients (869.16\u00a0\u00b1\u00a0242.83\u00a0pg\/ml versus 369.38\u00a0\u00b1\u00a0209.7\u00a0pg\/ml, respectively; p\u00a0&lt;\u00a00.0001). The mean aqueous IL\u20101<jats:italic>\u03b1<\/jats:italic> level was also significantly higher in HSO patients than in PDMS patients (81.40\u00a0\u00b1\u00a036.9\u00a0pg\/ml versus 40.8\u00a0\u00b1\u00a032.5\u00a0pg\/ml, respectively; p\u00a0=\u00a00.002). In HSO, a moderate positive correlation between the endotamponade duration and both PGE<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.44; p\u00a0=\u00a00.05) and IL\u20101<jats:italic>\u03b1<\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.48; p\u00a0=\u00a00.033) levels was observed. In PDMS, a strong positive correlation between the endotamponade duration and both PGE<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.89; p\u00a0&lt;\u00a00.0001) and IL\u20101<jats:italic>\u03b1<\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.68; p\u00a0=\u00a00.006) levels was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although both HSO and PDMS yielded favourable success rates in the surgical treatment of complicated retinal detachments, HSO triggered a more severe inflammatory reaction, in a time\u2010dependent manner.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13830","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T13:28:13Z","timestamp":1528118893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Comparative assessment of intraocular inflammation following standard or heavy silicone oil tamponade: a prospective study"],"prefix":"10.1111","volume":"97","author":[{"given":"Francesco","family":"Semeraro","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-3662","authenticated-orcid":false,"given":"Andrea","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Morescalchi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gambicorti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vezzoli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialties Radiological Sciences and Public Health \u2013 Section\u00a0of Legal Medicine University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Parmeggiani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences University of Molise Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0876-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)99023-6"},{"key":"e_1_2_5_4_1","first-page":"64","article-title":"Early decomposition of retained heavy silicone oil droplets","volume":"7","author":"Banaee T","year":"2012","journal-title":"J Ophthalmic Vis Res"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1962.00960030594005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903300103"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199212031-00008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.2.179"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02144130"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-1039-z"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0941"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702784"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/574825"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31771-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.156922"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0110-8"},{"key":"e_1_2_5_17_1","first-page":"2694","article-title":"Role of blood components in ocular silicone oil emulsification. 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