{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:52:11Z","timestamp":1789674731190,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. Nasser Al-Rashid Research Chair in Ophthalmology"},{"name":"Interuniversity Attraction Poles Programme initiated by the Belgian Science Policy Office"},{"name":"Research Foundation - Flanders"},{"name":"C1 funding"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To determine the concentrations of the CC<\/jats:styled-content> chemokines CCL<\/jats:styled-content>2, CCL<\/jats:styled-content>7, CCL<\/jats:styled-content>8, CCL<\/jats:styled-content>11, CCL<\/jats:styled-content>13, CCL<\/jats:styled-content>20, CCL<\/jats:styled-content>24 and CCL<\/jats:styled-content>26 in aqueous humour (AH<\/jats:styled-content>) samples from patients with specific uveitic entities.<\/jats:p><\/jats:sec>Methods<\/jats:title>Aqueous humour samples from patients with active uveitis associated with Beh\u00e7et's disease (BD<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a013), sarcoidosis (n<\/jats:italic>\u00a0=\u00a08), HLA<\/jats:styled-content>\u2010B27\u2010related inflammation (n<\/jats:italic>\u00a0=\u00a012), Vogt\u2013Koyanagi\u2013Harada (VKH<\/jats:styled-content>) disease (n<\/jats:italic>\u00a0=\u00a012) and control patients (n<\/jats:italic>\u00a0=\u00a09) were assayed with the use of a multiplex assay.<\/jats:p><\/jats:sec>Results<\/jats:title>When considering all uveitis patients as one group, all chemokine levels except CCL<\/jats:styled-content>2 were significantly increased compared to controls. CCL<\/jats:styled-content>8, CCL<\/jats:styled-content>13 and CCL<\/jats:styled-content>20 were the most strongly upregulated, 48\u2010fold, 118\u2010fold and 173\u2010fold, respectively, above control AH<\/jats:styled-content> levels. CCL<\/jats:styled-content>8 and CCL<\/jats:styled-content>13 levels were significantly higher in HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis than in sarcoidosis and VKH<\/jats:styled-content> disease. CCL<\/jats:styled-content>20 levels were significantly higher in HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis than in BD<\/jats:styled-content>, sarcoidosis and VKH<\/jats:styled-content> disease. In addition, CCL<\/jats:styled-content>20 levels were significantly higher in BD<\/jats:styled-content> than in VKH<\/jats:styled-content> disease. In HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis, CCL<\/jats:styled-content>8, CCL<\/jats:styled-content>13 and CCL<\/jats:styled-content>20 were upregulated 111\u2010fold, 255\u2010fold and 465\u2010fold, respectively, compared with controls. CCL<\/jats:styled-content>8, CCL<\/jats:styled-content>13 and CCL<\/jats:styled-content>20 levels were significantly higher in nongranulomatous uveitis (BD<\/jats:styled-content> and HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis) than in granulomatous uveitis (sarcoidosis and VKH<\/jats:styled-content> disease).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Immune responses mediated by CCL<\/jats:styled-content>8, CCL<\/jats:styled-content>13 and CCL<\/jats:styled-content>20 appear to be more potent in nongranulomatous uveitis, particularly in HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13835","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T12:43:01Z","timestamp":1537620181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The CC<\/scp> chemokines CCL<\/scp>8, CCL<\/scp>13 and CCL<\/scp>20 are local inflammatory biomarkers of HLA<\/scp>\u2010B27\u2010associated uveitis"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-8617","authenticated-orcid":false,"given":"Ahmed M.","family":"Abu El\u2010Asrar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"},{"name":"Dr. Nasser Al\u2010Rashid Research Chair in Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Berghmans","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research Department of Microbiology and Immunology University of Leuven KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Al\u2010Obeidan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla W.","family":"Gikandi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Opdenakker","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research Department of Microbiology and Immunology University of Leuven KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Van Damme","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research Department of Microbiology and Immunology University of Leuven KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Struyf","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research Department of Microbiology and Immunology University of Leuven KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702342"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12127"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19758"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2014.939197"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.4049\/jimmunol.153.7.3155","article-title":"Monocyte chemotactic protein\u20102, monocyte chemotactic protein\u20103, and fibroblast\u2010induced cytokine. 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