{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:52:16Z","timestamp":1791654736669,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bagenkop-Nielsen Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the prevalence of amblyopia and associated biometric factors in Danish children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Determination of best\u2010corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>) using <jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content> charts, non\u2010cycloplegic subjective refractioning guided by automated refractometry, axial length and corneal curvature, fundus photography and optical coherence tomography (OCT) in 1335 children from the population\u2010based Copenhagen Child Cohort 2000 (<jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content>2000) Eye Study. Birth data were obtained from the Danish Medical Birth Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age of children was 11.7 (\u00b10.4) years, and 47% were boys. Amblyopia prevalence was 1.5 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.8\u20132.2) %. Unilateral amblyopic eyes [<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>\u00a0&lt;\u00a080 <jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content> letters (0.8 snellen) and \u22652 lines difference between the eyes] was 0.6 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.3\u20131.0) mm shorter, 1.34 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.30\u20132.37) D more hyperopic and had 0.79 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.14\u20131.44) D more astigmatism compared with fellow eyes. Compared with the right eyes of the non\u2010amblyopic children, unilateral amblyopic eyes were 1.0 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.5\u20131.6) mm shorter, 2.48 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 1.11\u20133.86) D more hyperopic, 1.09 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 0.43\u20131.75) D more astigmatic and had a 47 (95% <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content> 13\u201381) <jats:italic>\u03bc<\/jats:italic>m thicker subfoveal choroid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amblyopia was found in 1.5% of Danish children born 22\u00a0years after the inception of the nationwide preschool visual screening programme. Amblyopia was associated with anisometropia, astigmatism, a thicker subfoveal choroid and a history of childhood strabismus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13842","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T03:50:40Z","timestamp":1538538640000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Visual acuity and amblyopia prevalence in 11\u2010 to 12\u2010year\u2010old Danish children from the Copenhagen Child Cohort 2000"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-123X","authenticated-orcid":false,"given":"Mathias Hvidtfelt","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger Christine","family":"Munch","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Ophthalmology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Mette","family":"Skovgaard","sequence":"additional","affiliation":[{"name":"Institute of Public Health University of Copenhagen Copenhagen Denmark"},{"name":"National Institute of Public Health University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else Marie","family":"Olsen","sequence":"additional","affiliation":[{"name":"Institute of Public Health University of Copenhagen Copenhagen Denmark"},{"name":"Centre for Clinical Research and Prevention Capital Region, Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Kessel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4461"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.04.034"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12639"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68581-4"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1986.tb06898.x"},{"key":"e_1_2_5_7_1","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen LB","year":"1998","journal-title":"Dan Med Bull"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb00926.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8108"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13476"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000583"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2915261"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2001.790609.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.6.878"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13650"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14034940510005662"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1991.tb02063.x"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.13842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.13842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:37:15Z","timestamp":1694309835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.13842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/aos.13842"],"URL":"https:\/\/doi.org\/10.1111\/aos.13842","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}