{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:30:04Z","timestamp":1792571404852,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLIF 340"],"award-info":[{"award-number":["KLIF 340"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Abnormal autoregulation of optic nerve head blood flow (<jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content>) has been postulated to play an important role in primary open\u2010angle glaucoma (<jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content>). We used laser Doppler flowmetry (<jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content>) to estimate quantitatively the <jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content> and compared <jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content> autoregulation between glaucoma patients and healthy controls during isometric exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> and 40 healthy age\u2010 and sex\u2010matched subjects underwent three periods of isometric exercise, each consisting of 2\u00a0min of handgripping. Optic nerve head blood flow (<jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content>) was measured continuously using <jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content>. Systemic blood pressure, intraocular pressure and ocular perfusion pressure were assessed in all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Isometric exercise was associated with an increase in ocular perfusion pressure during all handgripping periods in both groups (p\u00a0&lt;\u00a00.001). However, there was no change in <jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content> in either group. Three of the glaucoma patients and two of the healthy subjects showed a consistent 10% decrease in blood flow during isometric exercise, in spite of an increase in their blood pressure. This difference between groups was not significant (p\u00a0=\u00a00.61). Four other glaucoma subjects showed a consistent increase in blood flow of more than 10% during isometric exercise, whereas this was not seen in healthy subjects (p\u00a0=\u00a00.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that abnormal <jats:styled-content style=\"fixed-case\">ONHBF<\/jats:styled-content> autoregulation is more often seen in patients with <jats:styled-content style=\"fixed-case\">POAG<\/jats:styled-content> than healthy control subjects. The relationship to the glaucoma disease process is currently unknown and requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13850","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T12:57:18Z","timestamp":1537102638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Optic nerve head blood flow regulation during changes in arterial blood pressure in patients with primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-762X","authenticated-orcid":false,"given":"Ahmed M.","family":"Bata","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Fondi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Medical 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