{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:02:44Z","timestamp":1788631364983,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200716"],"award-info":[{"award-number":["81200716"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To investigate changes in subfoveal choroidal thickness (SFC<\/jats:styled-content>hT) during orthokeratology (Ortho\u2010K) lens wear and after its cessation and the association of short\u2010term change in SFC<\/jats:styled-content>hT with the long\u2010term eye elongation in Ortho\u2010K subjects.<\/jats:p><\/jats:sec>Design<\/jats:title>A prospective clinical trial.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty myopic children aged between 9 and 14\u00a0years were enrolled. Twenty\u2010nine subjects continuously wore Ortho\u2010K lens for 12\u00a0months and discontinued for 1\u00a0month. Twenty\u2010one subjects wearing single vision distance spectacles for 12\u00a0months were included as the control group. SFC<\/jats:styled-content>hT was assessed using optical coherence tomography. Ocular parameters, including axial length (AL<\/jats:styled-content>), central corneal thickness (CCT<\/jats:styled-content>), anterior chamber depth (ACD<\/jats:styled-content>), lens thickness (LT<\/jats:styled-content>) and apical corneal power (ACP<\/jats:styled-content>), were also measured.<\/jats:p><\/jats:sec>Results<\/jats:title>After 12\u00a0months of follow\u2010up, AL<\/jats:styled-content> elongation was larger and SFC<\/jats:styled-content>hT change was smaller in the control group compared to the Ortho\u2010K group (both p\u00a0<\u00a00.001). In the Ortho\u2010K group, SFC<\/jats:styled-content>hT increased by 16\u00a0\u03bc<\/jats:italic>m from baseline at the 1\u2010month visit (p\u00a0<\u00a00.001), and the magnitude of choroidal thickening remained unchanged at the 6\u2010 and 12\u2010month visit (p\u00a0=\u00a00.289). One month after discontinuation of Ortho\u2010K lens, SFC<\/jats:styled-content>hT and ocular parameters of the anterior segment, including ACP<\/jats:styled-content>, CCT<\/jats:styled-content> and ACD<\/jats:styled-content> recovered to baseline level (All p\u00a0>\u00a00.05), and AL<\/jats:styled-content> increased by 0.23\u00a0\u00b1\u00a00.18\u00a0mm compared to baseline (p\u00a0=\u00a00.018). SFC<\/jats:styled-content>hT change at 1\u2010month was negatively associated with AL<\/jats:styled-content> change at 13\u2010month (standard \u03b2<\/jats:italic>, \u22120.581, p\u00a0=\u00a00.001) after adjusting for other influencing factors, including baseline age and the ocular parameters.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Subfoveal ChT (SFChT) significantly increased after short\u2010term Ortho\u2010K lens treatment and the increase maintained throughout the period of treatment. One month after Ortho\u2010K lens cessation, SFC<\/jats:styled-content>hT, ACP<\/jats:styled-content>, CCT<\/jats:styled-content> and ACD<\/jats:styled-content> returned to baseline. Short\u2010term response in SFC<\/jats:styled-content>hT is associated with long\u2010term change in AL<\/jats:styled-content> in children undergoing Ortho\u2010K lens and may be a predictor for the effectiveness of the treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13866","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T02:51:35Z","timestamp":1538794295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length"],"prefix":"10.1111","volume":"97","author":[{"given":"Zhouyue","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University Guangzhou 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