{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:55:56Z","timestamp":1776358556757,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To investigate the frequency of primary angle closure (PAC<\/jats:styled-content>) and primary angle closure glaucoma (PACG<\/jats:styled-content>) in patients with retinal vein occlusion (RVO<\/jats:styled-content>) based on a hospital population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 375 consecutive cases newly diagnosed with RVO<\/jats:styled-content> by fluorescein fundus angiography at a single eye centre in Peking were reviewed. Gonioscopy was performed in all patients. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology. Retinal vein occlusion was classified as central retinal vein occlusion (CRVO<\/jats:styled-content>), hemicentral retinal vein occlusion (HRVO<\/jats:styled-content>), or branch retinal vein occlusion (BRVO<\/jats:styled-content>), and as arteriovenous crossing RVO<\/jats:styled-content> (AV<\/jats:styled-content>\u2010RVO<\/jats:styled-content>), optic cup RVO<\/jats:styled-content> (OC<\/jats:styled-content>\u2010RVO<\/jats:styled-content>), optic nerve RVO<\/jats:styled-content> without optical nerve head swelling (NONHS<\/jats:styled-content>\u2010RVO<\/jats:styled-content>), or RVO<\/jats:styled-content> with optical nerve head swelling (ONHS<\/jats:styled-content>\u2010RVO<\/jats:styled-content>) based on the site of venous occlusion. Percentage of PAC<\/jats:styled-content> or PACG<\/jats:styled-content> for each type of RVO<\/jats:styled-content> were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>PACG<\/jats:styled-content> had a frequency of 4.1% [95% confidence interval (CI<\/jats:styled-content>) 2.2\u20136.9%] in 317 RVO<\/jats:styled-content> patients [5.3% (95% CI<\/jats:styled-content> 2.0\u201311.2%) in CRVO<\/jats:styled-content>, 8.8% (95% CI<\/jats:styled-content> 1.9\u201323.7%) in HRVO<\/jats:styled-content>, and 1.9% (95% CI<\/jats:styled-content> 0.4\u20135.4%) in BRVO<\/jats:styled-content>]. Primary angle closure (PAC<\/jats:styled-content>) had a frequency of 2.9% (95% CI<\/jats:styled-content> 1.4\u20135.5%) in RVO<\/jats:styled-content>. PAC<\/jats:styled-content>\/PACG<\/jats:styled-content> had a frequency of 11.5% (95% CI<\/jats:styled-content> 6.3\u201318.9%) in CRVO<\/jats:styled-content>, 8.8% (95% CI<\/jats:styled-content> 1.9\u201323.7%) in HRVO<\/jats:styled-content> and 3.1% (95% CI<\/jats:styled-content> 1.0\u20137.1%) in BRVO<\/jats:styled-content>. PAC<\/jats:styled-content>\/PACG<\/jats:styled-content> was significantly more prevalent in NONHS<\/jats:styled-content>\u2010RVO<\/jats:styled-content> [18.9% (95% CI<\/jats:styled-content> 9.4\u201332.0%)] than in ONHS<\/jats:styled-content>\u2010RVO<\/jats:styled-content> [6.5% (95% CI<\/jats:styled-content> 2.1\u201314.5%)], AV<\/jats:styled-content>\u2010RVO<\/jats:styled-content> [3.1% (95% CI<\/jats:styled-content> 0.9\u20137.8%)], and OC<\/jats:styled-content>\u2010RVO<\/jats:styled-content> [2.3% (95% CI<\/jats:styled-content> 0.1\u201312.3%)].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The overall frequency of PAC<\/jats:styled-content>\/PACG<\/jats:styled-content> was much higher in patients with RVO<\/jats:styled-content> (especially CRVO<\/jats:styled-content>) than that in the general population. Eyes with PAC<\/jats:styled-content>\/PACG<\/jats:styled-content> may undergo mechanical changes in the lamina cribrosa of the optic disc, resulting in RVO<\/jats:styled-content>. Angle\u2010closure conditions should be borne in mind when investigating Chinese patients with RVO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13879","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:14:59Z","timestamp":1537578899000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Primary angle closure and primary angle closure glaucoma in retinal vein occlusion"],"prefix":"10.1111","volume":"97","author":[{"given":"Ke","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-1617","authenticated-orcid":false,"given":"Lingling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32884-3"},{"key":"e_1_2_5_3_1","first-page":"153","article-title":"Risk factors associated with branch vs. central retinal vein occlusion","volume":"21","author":"Appiah AP","year":"1989","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2012.11.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.5.572"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00922-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(51)92277-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1961.tb00274.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000040365002"},{"key":"e_1_2_5_10_1","first-page":"111","article-title":"Retinal vein occlusion","volume":"52","author":"Clement DB","year":"1968","journal-title":"Br J Ophthalmol"},{"key":"e_1_2_5_11_1","first-page":"229","article-title":"Venous obstruction and neovascularization at the disc in chronic glaucoma","volume":"77","author":"Dobree JH","year":"1957","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1965.00970030661012"},{"key":"e_1_2_5_13_1","volume-title":"Text\u2010book of ophthalmology. 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