{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:44:10Z","timestamp":1788054250824,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study whether a clinically significant increase in intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) occurs during simulated sleep conditions with the subject's head turned comfortably into a pillow (the simulated sleep position) and the effect of protective glasses on any such <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> rise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A specially developed electronic epipalpebral pressure (<jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content>) sensor was attached to an eyelid of the right eye of all participants: 11 patients with primary open\u2010angle glaucoma and 11 healthy volunteers. During calibration, mechanical pressure was applied to the <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content> sensor taped to the lower eyelid and the <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was measured simultaneously at the slit lamp by Goldmann applanation tonometry. The <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content> was increased in a stepwise fashion to assess the relationship between <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> for each individual eye. Thereafter, <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content> (with the sensor now taped to the upper eyelid) measurements were performed in the simulated sleep position, both with and without protective glasses. The <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content> was determined in each individual eye, and the estimated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was then inferred from the established <jats:styled-content style=\"fixed-case\">EPP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the simulated sleep position, the mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> increased by an estimated 19.6\u00a0mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: 7.5; range 11.6\u201332.8; p\u00a0&lt;\u00a00.0001) in the patient group and 28.0\u00a0mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: 9.6; range 12.3\u201341.1); p\u00a0&lt;\u00a00.0001) in the control group. When the subjects wore protective glasses, the mean estimated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> decreased again by 16.3\u00a0mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: 5.6; range 9.8\u201328.1; p\u00a0&lt;\u00a00.0001) in the patient group and 25.1\u00a0mmHg (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>: 8.2; range 11.7\u201338.3; p\u00a0=\u00a0&lt;0.0001) in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Turning the head into a pillow gave a large and clinically significant increase in the estimated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> in the simulated sleep position. With protective glasses, however, the increase in estimated <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> was almost absent. Therefore, protective shielding of the eyes during sleep may be a treatment option in glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13881","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T02:31:12Z","timestamp":1539052272000},"page":"795-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is a pillow a risk factor for glaucoma?"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-8236","authenticated-orcid":false,"given":"Ida A.","family":"van Meurs","sequence":"first","affiliation":[{"name":"The Rotterdam Ophthalmic Institute The Rotterdam Eye Hospital Rotterdam the Netherlands"},{"name":"Department of Ophthalmology The VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-0284","authenticated-orcid":false,"given":"Gijs","family":"Thepass","sequence":"additional","affiliation":[{"name":"The Rotterdam Ophthalmic Institute The Rotterdam Eye Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.","family":"Stuij","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Maasstad Hospital Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Geert","family":"Bollemeijer","sequence":"additional","affiliation":[{"name":"The Rotterdam Ophthalmic Institute The Rotterdam Eye Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans G.","family":"Lemij","sequence":"additional","affiliation":[{"name":"The Rotterdam Ophthalmic Institute The Rotterdam Eye Hospital Rotterdam the 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