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Less is known about polypoidal choroidal vasculopathy (PCV<\/jats:styled-content>), which is an important differential diagnosis to neovascularAMD<\/jats:styled-content>. Here, we report plasma markers of inflammation with age (inflammaging) in patients withPCV<\/jats:styled-content>, patients with neovascularAMD<\/jats:styled-content>and a healthy age\u2010matched control group.<\/jats:p><\/jats:sec>Methods<\/jats:title>We isolated plasma from fresh venous blood obtained from participants (n<\/jats:italic>\u00a0=\u00a090) with eitherPCV<\/jats:styled-content>, neovascularAMD<\/jats:styled-content>, or healthy maculae. Interleukin(IL<\/jats:styled-content>)\u20101\u03b2<\/jats:italic>,IL<\/jats:styled-content>\u20106,IL<\/jats:styled-content>\u20108,IL<\/jats:styled-content>\u201010 and tumour necrosis factor receptor 2 (TNF<\/jats:styled-content>\u2010R2) were measured using U\u2010PLEX<\/jats:styled-content>Human Assays. Routine plasma C\u2010reactive protein (CRP<\/jats:styled-content>) was measured using Dimension Vista 1500.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients withPCV<\/jats:styled-content>had plasma levels ofIL<\/jats:styled-content>\u20101\u03b2<\/jats:italic>,IL<\/jats:styled-content>\u20106,IL<\/jats:styled-content>\u20108,IL<\/jats:styled-content>\u201010 andTNF<\/jats:styled-content>\u2010R2 similar to that in healthy controls. Patients with neovascularAMD<\/jats:styled-content>had significantly higher plasmaIL<\/jats:styled-content>\u20101\u03b2<\/jats:italic>,IL<\/jats:styled-content>\u20106 andIL<\/jats:styled-content>\u201010 than healthy controls, whereas no significant differences were observed for plasmaIL<\/jats:styled-content>\u20108 andTNF<\/jats:styled-content>\u2010R2. Differences between plasmaIL<\/jats:styled-content>\u20101\u03b2<\/jats:italic>,IL<\/jats:styled-content>\u20106 andIL<\/jats:styled-content>\u201010 possessed a positive but weak ability in discriminating neovascularAMD<\/jats:styled-content>fromPCV<\/jats:styled-content>. Both patients withPCV<\/jats:styled-content>and patients with neovascularAMD<\/jats:styled-content>had significantly higher levels of routine plasmaCRP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients withPCV<\/jats:styled-content>differ from patients with neovascularAMD<\/jats:styled-content>in terms of plasma inflammaging profile. Apart from increasedCRP<\/jats:styled-content>, no signs of inflammaging were observed in patients withPCV<\/jats:styled-content>. In patients with neovascularAMD<\/jats:styled-content>, we find a specific angiogenesis\u2010twisted inflammaging profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13886","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T02:50:41Z","timestamp":1538794241000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Plasma markers of chronic low\u2010grade inflammation in polypoidal choroidal vasculopathy and neovascular age\u2010related macular degeneration"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6620-5365","authenticated-orcid":false,"given":"Yousif","family":"Subhi","sequence":"first","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-7296","authenticated-orcid":false,"given":"Marie","family":"Krogh Nielsen","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Rue","family":"Molbech","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amardeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Department of Clinical Sciences Lund Ophthalmology Skane University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens Holst","family":"Nissen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Science University of Copenhagen Copenhagen Denmark"},{"name":"Eye Research Unit Department of Immunology and Microbiology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben Lykke","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Clinical Eye Research Division Department of Ophthalmology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"985","article-title":"Association of gene polymorphism with serum levels of inflammatory and angiogenic factors in Pakistani patients with age\u2010related macular degeneration","volume":"21","author":"Ambreen F","year":"2015","journal-title":"Mol Vis"},{"key":"e_1_2_5_3_1","first-page":"285","article-title":"The clinical impact of systemic low\u2010level inflammation in elderly populations. 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