{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:50:07Z","timestamp":1792277407221,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010729","name":"Carl and Emily Fuchs Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Like the classic trabeculectomy, the minimally invasive, ab interno <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content> Glaucoma Gel Microstent (<jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content>) creates a filtration bleb in the conjunctiva. The goal of this study was to investigate internal bleb morphology over time with anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) after <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content> implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, single\u2010centre, single\u2010armed cohort study, blebs were characterized using <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> in 78 eyes of 60 patients at day 1, at weeks 1 and 2 and at months 1, 3, 6, 9 and 12 after <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GGM<\/jats:styled-content> implantation in patients with open\u2010angle glaucoma. Morphological bleb characteristics were correlated with <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> and surgical success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anterior segment optical coherence tomography data indicate early and late bleb changes in the course of 12\u00a0months. <jats:italic>Uniform<\/jats:italic> blebs in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>s showed higher <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>s at all examinations between week 1 (17.7\u00a0\u00b1\u00a04.8\u00a0mmHg versus 11.3\u00a0\u00b1\u00a07.1\u00a0mmHg, p\u00a0=\u00a00.001) and month 3 (16.4\u00a0\u00b1\u00a06.1 versus 13.4\u00a0\u00b1\u00a06.1, p\u00a0=\u00a00.04). <jats:italic>Subconjunctival tissue separation<\/jats:italic> bleb morphology was associated with lower mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>s during the course of 12\u00a0months (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.75, p\u00a0=\u00a00.031). Predictors for surgical failure at month 12 were <jats:italic>microcystic multiform<\/jats:italic> bleb morphology in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> at month 3 (60% versus 15%, relative risk 4.0, p\u00a0=\u00a00.043) and <jats:italic>uniform<\/jats:italic> bleb morphology at month 9 (33% versus 23%, relative risk 1.4, p\u00a0=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bleb appearance after <jats:styled-content style=\"fixed-case\">XEN<\/jats:styled-content> surgery seems to be different to classic trabeculectomy literature. The present data suggest correlation of <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> and surgical long\u2010term success with bleb morphology in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. Prevalence of small diffuse cysts is directly associated with lower <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>s, while cystic encapsulation at 3\u00a0months predicts higher surgical failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13902","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T12:22:40Z","timestamp":1535631760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Longitudinal bleb morphology in anterior segment <scp>OCT<\/scp> after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-7330","authenticated-orcid":false,"given":"Markus","family":"Lenzhofer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry University Clinic Salzburg Paracelsus Medical University Salzburg 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