{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:12:23Z","timestamp":1788480743859,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Economy, Industry and Competitiveness of Spain within the program Ram\u00f3n y Cajal","award":["RYC-2016-20471"],"award-info":[{"award-number":["RYC-2016-20471"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate and compare the symptomatology and clinical findings in hyposecretory dry eye of the treatment with platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) and artificial tears of sodium hyaluronate (<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blind single\u2010centre prospective comparative randomized study including 83 patients with hyposecretory dry eye and mean age of 64.0\u00a0years. Two groups were differentiated depending on the treatment applied: 44 patients treated with <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> group), and 39 patients treated with artificial tears of <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> group). Changes in Schimer test, tear osmolarity, corneal and conjunctival staining, tear film break\u2010up time (<jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BUT<\/jats:styled-content>), conjunctival hyperaemia, dry eye\u2010related symptoms with the Ocular Surface Disease Index questionnaire, and caliciform cell density were evaluated during 30\u00a0days of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly larger reduction in symptomatology (p\u00a0&lt;\u00a00.001), visual improvement (p\u00a0&lt;\u00a00.001), reduction in hyperaemia (p\u00a0&lt;\u00a00.001), and corneal and conjunctival staining (p\u00a0&lt;\u00a00.001), increment of Schirmer test outcome (p\u00a0\u2264\u00a00.005), and reduction of osmolarity were found in the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> group in both eyes compared to <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> group at 15 and 30\u00a0days of treatment. Likewise, a significantly higher increment of caliciform cell density (p\u00a0&lt;\u00a00.001) was found in the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> group. Strong and statistically significant correlations were found in the <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> group of the change achieved in visual acuity, hyperaemia, osmolarity, and conjunctival and corneal staining with the baseline values of these variables (p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> treatment in hyposecretory dry eye induces a more significant positive effect over symptomatology and different dry eye signs than <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>, especially in moderate and severe cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13907","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T04:39:14Z","timestamp":1542602354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Efficacy and safety of treatment of hyposecretory dry eye with platelet\u2010rich plasma"],"prefix":"10.1111","volume":"97","author":[{"given":"V\u00edctor","family":"Garc\u00eda\u2010Conca","sequence":"first","affiliation":[{"name":"Department of Ophthalmology San Juan University Hospital Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Abad\u2010Collado","sequence":"additional","affiliation":[{"name":"Mabad Laboratories Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R","family":"Hueso\u2010Abancens","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology San Juan University 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