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Spectral\u2010domain optical coherence tomography imaging was conducted before surgery and at 28\u00a0days. Information about medication of the participants was gathered from The National Archive of Health Information (Kanta), an electronic pharmaceutical database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Systemic medication with angiotensin converting enzyme inhibitor\/angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor antagonists (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), beta\u2010blockers (<jats:italic>\u03b2<\/jats:italic>\u2010blockers) (p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.002), calcium channel blockers (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s) (p<jats:italic>\u00a0&lt;\u00a0<\/jats:italic>0.001), nitrates (p<jats:italic>\u00a0=<\/jats:italic>0.021) and lipophilic <jats:styled-content style=\"fixed-case\">HMG<\/jats:styled-content>\u2010CoA reductase inhibitors (statins) (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) were more frequently prescribed to diabetic compared with nondiabetic patients. In eyes with steroid monotherapy (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>135), concomitant systemic medication with <jats:italic>\u03b2<\/jats:italic>\u2010blockers (12.9\u00a0\u00b1\u00a024.0\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 28.6\u00a0\u00b1\u00a059.5\u00a0<jats:italic>\u03bc<\/jats:italic>m, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.045), <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s (12.0\u00a0\u00b1\u00a022.1\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 26.3\u00a0\u00b1\u00a055.6\u00a0<jats:italic>\u03bc<\/jats:italic>m, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.041) and statins (12.9\u00a0\u00b1\u00a022.8\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 30.0\u00a0\u00b1\u00a061.9\u00a0<jats:italic>\u03bc<\/jats:italic>m, p<jats:italic>\u00a0=\u00a0<\/jats:italic>0.038) attenuated a change in central retinal thickness (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) when compared to patients not receiving medication. In multivariable analysis, the use of <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s remained as an independent protective factor against macular swelling at 28\u00a0days (\u22120.23; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.43 to \u22120.04]; p<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.021), when all systemic medications showing statistical significance were included (<jats:italic>i.e. \u03b2<\/jats:italic>\u2010blockers, <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>s and statins) together with diabetes status. In eyes with nonsteroidal anti\u2010inflammatory drug (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>) monotherapy (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>67) and steroid and <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> combination therapy (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>67), <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> increase was moderate both with and without use of systemic medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systemic vasoactive medication may be protective against <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> change induced by cataract surgery in eyes at risk of <jats:styled-content style=\"fixed-case\">PCME<\/jats:styled-content> such as those with postoperative steroid monotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13911","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T05:09:03Z","timestamp":1536210543000},"page":"178-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systemic use of calcium channel blockers associated with less increase in central retinal thickness after uncomplicated cataract surgery"],"prefix":"10.1111","volume":"97","author":[{"given":"Reeta","family":"Danni","sequence":"first","affiliation":[{"name":"Helsinki Retina Research Group University of Helsinki Helsinki Finland"},{"name":"Department of Ophthalmology Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-8872","authenticated-orcid":false,"given":"Claudia","family":"Taipale","sequence":"additional","affiliation":[{"name":"Helsinki Retina Research Group University 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