{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:53:36Z","timestamp":1790553216599,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["394321"],"award-info":[{"award-number":["394321"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare topical cyclosporine\u2010A 2% eye drop (Cs\u2010A) with prednisolone acetate 1% eye drop for treatment of herpetic stromal keratitis (HSK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized clinical trial, 38 eyes of 33 patients with HSK were randomly assigned to receive either 2% Cs\u2010A or 1% prednisolone acetate eye drops. All subjects received oral acyclovir 400\u00a0mg twice a day. Slit\u2010lamp examination, Scheimpflug tomography corneal optical densitometry (Pentacam\u00ae, Oculus Inc., Wetzlar, Germany), best\u2010corrected visual acuity (BCVA), and intra\u2010ocular pressure (IOP) were evaluated at the first visit, and 14 and 30\u00a0days after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within\u2010group analysis revealed significant improvement of total cornea optical density after 30\u00a0days of treatment in both groups (30.3\u00a0\u00b1\u00a010.5 to 28.3\u00a0\u00b1\u00a09.8, p\u00a0&lt;\u00a00.001 for prednisolone group, and 30.5\u00a0\u00b1\u00a08.8 to 28.8\u00a0\u00b1\u00a08.3 p\u00a0&lt;\u00a00.001 for Cs\u2010A group, mean\u00a0\u00b1\u00a0SD). We were not able to disclose any significant difference between the two groups regarding the improvement of cornea optical density (p\u00a0=\u00a00.66). Best\u2010corrected visual acuity (BCVA) logMAR significantly improved in both groups after 30\u00a0days of treatment (0.20\u00a0\u00b1\u00a00.52, p\u00a0=\u00a00.002 in prednisolone group, and 0.24\u00a0\u00b1\u00a00.31, p\u00a0&lt;\u00a00.001 in Cs\u2010A group, mean\u00a0\u00b1\u00a0SD). Analysis between groups did not show a significant difference of BCVA improvement (p\u00a0=\u00a00.45). We did not observe any severe side effect attributable to drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cs\u2010A 2% and prednisolone acetate 1% topical eye drops are effective for treatment of HSK.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13913","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T18:20:48Z","timestamp":1538763648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Topical cyclosporine\u2010A versus prednisolone for herpetic stromal keratitis: a randomized controlled trial"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-8811","authenticated-orcid":false,"given":"Alireza","family":"Peyman","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Isfahan University of Medical Sciences Isfahan 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