{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:48:45Z","timestamp":1782168525790,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health and by Fondazione Roma"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the diagnostic accuracy of minimum rim width (<jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content>), peripapillary retinal nerve fibre layer (<jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content>) and multilayered macular analysis by Spectralis <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (Heidelberg Engineering, Germany) in discriminating perimetric glaucoma at different stages of the disease from healthy eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicentre, prospective, evaluation of diagnostic tests study, multilayered macular analysis and <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> were obtained from one eye of 197 glaucoma (76 early, 68 moderate and 53 advanced) and of 83 healthy controls from the Multicenter Italian Glaucoma Imaging Study (<jats:styled-content style=\"fixed-case\">MIGIS<\/jats:styled-content>). The reference standard for classifying eyes as glaucomatous and for staging the\u00a0disease was the visual field. The main outcome measures were area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) and sensitivity at fixed specificity (95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content> and average <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> showed the highest and similar diagnostic accuracy in both the whole study population (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.968 and 0.939) and early glaucoma (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.956 and 0.929). Among the macular parameters, the three innermost retinal layers combined as the Ganglion Cell Complex provided the highest diagnostic accuracy (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.931) in the whole population, which was statistically similar to that of average <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> but inferior to that of average <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content>. Compared to both average <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content>, all macular parameters showed statistically significant lower accuracy in early glaucoma, but accuracy in moderate and advanced glaucoma showed no statistically significant differences among three protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic accuracy of <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> pRNFL<\/jats:styled-content> and macular analysis by Spectralis <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> is overall good. <jats:styled-content style=\"fixed-case\">MRW<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pRNFL<\/jats:styled-content> analysis performs statistically and clinically better than macular analysis to discriminate early glaucoma from healthy eyes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13930","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T06:01:02Z","timestamp":1539928862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Macular versus nerve fibre layer versus optic nerve head imaging for diagnosing glaucoma at different stages of the disease: Multicenter Italian Glaucoma Imaging Study"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-0829","authenticated-orcid":false,"given":"Manuele","family":"Michelessi","sequence":"first","affiliation":[{"name":"IRCCS \u2013 Fondazione Bietti Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-2260","authenticated-orcid":false,"given":"Ivano","family":"Riva","sequence":"additional","affiliation":[{"name":"IRCCS \u2013 Fondazione Bietti Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Martini","sequence":"additional","affiliation":[{"name":"U.O. 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