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Conditional logistic regression assessed whether sociodemographic factors and specific systemic diseases were associated with the odds of keratoconus. Mortality was assessed with time\u2010to\u2010event analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment, non\u2010Europeans had more than threefold higher odds of keratoconus compared to Europeans (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.34; 96% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.94\u20133.80). Single persons had 27% higher odds (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.27; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20131.43), and divorced persons had 18% lower odds (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.82; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.68\u20130.97) of keratoconus compared with persons in a relationship. Persons living in cities with &lt;500 and 500\u20134999 inhabitants had 40% (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.60; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.51\u20130.71) and 30% (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.70; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.61\u20130.81) lower odds of keratoconus, respectively, compared with those living in the capital (&gt;1\u00a0000\u00a0000 inhabitants). Persons receiving government substitution had 68% higher odds of keratoconus (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.68; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.30\u20132.17) compared to self\u2010employed. Keratoconus patients had more than twofold higher odds of asthma (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.21; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.91\u20132.55), more than threefold higher odds of allergic rhinitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 3.44; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.75\u20134.30), more than sevenfold higher odds of atopic dermatitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 7.97; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 6.21\u201310.21) and 69% higher odds of depression (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.69; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.18\u20132.43). Mortality rates were similar among keratoconus patients and controls (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.02; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.90\u20131.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Danish keratoconus patients differ from controls on several sociodemographic factors and have higher risk of allergic rhinitis, asthma, atopic dermatitis and depression. They do not have excess mortality compared to controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13961","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T05:40:33Z","timestamp":1542174033000},"page":"497-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["A nationwide population\u2010based study of social demographic factors, associated diseases and mortality of keratoconus patients in Denmark from 1977 to 2015"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-9072","authenticated-orcid":false,"given":"Sashia","family":"Bak\u2010Nielsen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H.","family":"Ramlau\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Public Health Section\u00a0for Epidemiology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ivarsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleguer","family":"Plana\u2010Ripoll","sequence":"additional","affiliation":[{"name":"National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116481"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31817f815a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.63"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31828da95c"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8acd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12147"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Clinical and epidemiological features of keratoconus. 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