{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:04:44Z","timestamp":1790139884551,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR1404500"],"award-info":[{"award-number":["17ZR1404500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the associations of cytokine concentrations in aqueous humour with the severity of retinal vascular abnormalities, exudation and fibrosis in patients with Coats\u2019 disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Aqueous humour samples were collected in 23 paediatric patients (23 eyes) with Coats\u2019 disease and six age\u2010matched control patients (six eyes) with congenital cataract in this cross\u2010sectional, case\u2013control study. Through Cytometric Bead Array technology, six angiogenic, inflammatory and fibrotic cytokines were measured for their concentrations in aqueous humour. Ophthalmologic characteristics including retinal vessel abnormalities, exudation and fibrosis of Coats\u2019 disease were also clinically evaluated for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The aqueous levels of vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) (p\u00a0=\u00a00.006) and monocyte chemoattractant protein\u20101 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101) (p\u00a0&lt;\u00a00.001) were significantly higher in the Coats\u2019 disease group than in the control group. The concentrations of angiogenin were peaked in eyes with first\u2010grade vessels tortuosity (p\u00a0&lt;\u00a00.001), and also positively correlated with the severity of retinal capillary abnormalities (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.910, p\u00a0&lt;\u00a00.001). The concentrations of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.966, p\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> (<jats:italic>r\u00a0<\/jats:italic>=\u00a00. 765, p\u00a0=\u00a00.002) were significantly correlated with the extent of retinal exudation. The aqueous humour transforming growth factor\u2010\u03b2 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2) concentrations were higher in eyes with retinal fibrosis than in non\u2010fibrotic eyes with Coats\u2019 disease (p\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Coats\u2019 disease, angiogenin may act as a potential biomarker for retinal vascular abnormalities. The concentrations of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 may positively correlate with the severity of retinal exudation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13971","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T06:46:50Z","timestamp":1541832410000},"page":"319-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations of cytokine concentrations in aqueous humour with retinal vascular abnormalities and exudation in Coats\u2019 disease"],"prefix":"10.1111","volume":"97","author":[{"given":"Juan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology at Eye and ENT Hospital Shanghai Medical College Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration Fudan University 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