{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:27Z","timestamp":1787013867044,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30471861"],"award-info":[{"award-number":["30471861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n To explore the effectiveness and safety of vitrectomy for congenital cataract surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We searched PubMed, Science Direct, The Cochrane Library, China National Knowledge Infrastructure and the Wanfang Database. Two researchers extracted data and assessed paper quality independently. Posterior capsule opacification (\n PCO<\/jats:styled-content>\n ) or visual axis opacification (\n VAO<\/jats:styled-content>\n ), reoperation rate, visual acuity, intraocular lenses (\n IOL<\/jats:styled-content>\n ) deposit, synechias, uveitis, secondary glaucoma, low\u2010contrast sensitivity and\n IOL<\/jats:styled-content>\n decentration were compared.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 11 randomized controlled trials (\n RCT<\/jats:styled-content>\n s) with 634 congenital cataract eyes. Cases of posterior capsule opacification in vitrectomy group were significantly less than that of control group, with risk ratio (\n RR<\/jats:styled-content>\n ) of 0.15 [95% confidence interval (\n CI<\/jats:styled-content>\n ): 0.09, 0.26], and there was no heterogeneity (\n I<\/jats:italic>\n 2\u00a0<\/jats:sup>\n =\u00a00%, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.94). Reoperation rate in vitrectomy group was lower than that of control group either (\n RR<\/jats:styled-content>\n \u00a0=\u00a00.40, 95%\n CI<\/jats:styled-content>\n : 0.17, 0.94), and there was no heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00%, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.85). Best\u2010corrected visual acuity (\n BCVA<\/jats:styled-content>\n ) measured in Log\n MAR<\/jats:styled-content>\n unit of vitrectomy group was smaller, with a mean difference (\n MD<\/jats:styled-content>\n ) of \u22120.17 (95%\n CI<\/jats:styled-content>\n : \u22120.28, \u22120.05), and\n I<\/jats:italic>\n 2<\/jats:sup>\n was only 22%, indicating of a small heterogeneity. No statistical difference was found between two groups on\n IOL<\/jats:styled-content>\n deposit (\n RR<\/jats:styled-content>\n \u00a0=\u00a01.23, 95%\n CI<\/jats:styled-content>\n : 0.70, 2.17), and the heterogeneity was small (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a016%, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.31). No statistical difference was found between two groups on synechias (\n RR<\/jats:styled-content>\n \u00a0=\u00a01.08, 95%\n CI<\/jats:styled-content>\n : 0.60, 1.94), with a quite small heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a03%, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.38). No statistical difference was found between two groups on uveitis (\n RR<\/jats:styled-content>\n \u00a0=\u00a00.55, 95%\n CI<\/jats:styled-content>\n : 0.15, 2.01), and there was no heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00%, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.94). There was no statistical difference on\n IOP<\/jats:styled-content>\n either, with a\n MD<\/jats:styled-content>\n of 0.25 (95%\n CI<\/jats:styled-content>\n : \u22121.56, 2.07), and there was no heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u00a0=\u00a00%). Egger's test showed that there was no publication bias for all assessed outcomes. Low\u2010contrast sensitivity was better in the vitrectomy group. And no evidence indicated vitrectomy could lead to a higher risk on secondary glaucoma or\n IOL<\/jats:styled-content>\n decentration.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Vitrectomy helps lower the\n PCO<\/jats:styled-content>\n risk and reoperation risk after congenital cataract surgery, and also, vitrectomy helps patients gain a better\n BCVA<\/jats:styled-content>\n and achieve a better low\u2010contrast sensitivity, with no trade\u2010off on\n IOP<\/jats:styled-content>\n control,\n IOL<\/jats:styled-content>\n deposit, synechias, uveitis and secondary glaucoma. We recommend performing vitrectomy during congenital cataract surgery.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.13974","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T09:32:29Z","timestamp":1545211949000},"page":"233-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy and safety of vitrectomy for congenital cataract surgery: a systematic review and meta\u2010analysis based on randomized and controlled trials"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-887X","authenticated-orcid":false,"given":"Kai","family":"Cao","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital of Capital Medical University Beijing 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