{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:45:14Z","timestamp":1785797114180,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether exposure to antazoline\u2010naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All women giving live birth between 1997 and 2011 in Denmark were included in this nationwide cohort study. All women redeeming at least one prescription of antazoline\u2010naphazoline eye drops during the first 84\u00a0days of pregnancy were identified. Logistic regression was used to estimate the odds ratios of malformations among exposed offspring compared to non\u2010exposed offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 977\u00a0706 births between 1997 and 2011. A total of 3061 women (0.32%) were exposed to antazoline\u2010naphazoline eye drops in the first trimester of pregnancy. The rate of congenital malformations was 3.0% (<jats:italic>n\u00a0<\/jats:italic>=\u00a093) in exposed offspring and 3.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a033\u00a0594) in unexposed offspring. First\u2010trimester exposure to antazoline\u2010naphazoline was not associated with major congenital malformations overall (odds ratio: 0.88, 95% confidence interval: 0.71\u20131.09) or with any specific major malformation. The number of redeemed prescriptions was unchanged during all trimesters of pregnancy as compared to before and after pregnancy (p\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to antazoline\u2010naphazoline eye drops in the first trimester of pregnancy appears not to be associated with increased teratogenic risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13980","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T05:44:28Z","timestamp":1543297468000},"page":"505-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exposure to antazoline\u2010naphazoline eye drops during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-9573","authenticated-orcid":false,"given":"Vilde","family":"Thomseth","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Stavanger University Hospital Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Cejvanovic","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Laboratory of Clinical Pharmacology Copenhagen University Hospital Rigshospitalet and Glostrup Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen","family":"Jimenez\u2010Solem","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik E.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Laboratory of Clinical Pharmacology Copenhagen University Hospital Rigshospitalet and Glostrup Copenhagen Denmark"},{"name":"Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor Paaske","family":"Utheim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Stavanger University Hospital Stavanger Norway"},{"name":"Department of Clinical Medicine Faculty of Medicine University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon T.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"},{"name":"Laboratory of Clinical Pharmacology Copenhagen University Hospital Rigshospitalet and Glostrup Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"263","article-title":"The Danish national hospital register. 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