{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:44:10Z","timestamp":1792712650929,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (<jats:styled-content style=\"fixed-case\">qAF<\/jats:styled-content>) measurements in patients with early and intermediate age\u2010related macular degeneration (<jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content>), using the first approved and commercially available instrument.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 eyes of 22 patients (aged between 52 and 84\u00a0years) diagnosed with early and intermediate <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> were included. All eyes were imaged at day 1, 3\u00a0months and 6\u00a0months using a modified scanning laser ophthalmoscope, equipped with an internal fluorescent reference. Mean <jats:styled-content style=\"fixed-case\">qAF<\/jats:styled-content> values were calculated for the fovea and for each concentric ring of the Delori pattern. Repeatability and reliability were calculated using Bland\u2013Altman analysis and intraclass correlation (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean patient age was 73.5\u00a0\u00b1\u00a07.9\u00a0years. Sixteen patients (73%) were female. <jats:styled-content style=\"fixed-case\">qAF<\/jats:styled-content> repeatability of the eight segments in the middle ring of the Delori pattern (<jats:styled-content style=\"fixed-case\">qAF<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>8<\/jats:sub>) for between sessions was \u00b18.2%. Agreement at 3\u2010 and 6\u2010month follow\u2010up in eyes without retinal changes was \u00b18.3% and \u00b19.8%, respectively. Reliability of <jats:styled-content style=\"fixed-case\">qAF<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>8<\/jats:sub> was high for all images acquired [<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.98 (CI: 0.96\u20130.99), 0.97 (0.93\u20130.99) and 0.98 (0.92\u20130.99)]. Agreement at 3\u2010 and 6\u2010month follow\u2010up in eyes with retinal changes was \u00b118.1% and \u00b120.2%, respectively. Intraclass correlation (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) was slightly lower in eyes with retinal changes at 0.93 (0.84\u20130.97) and 0.96 (0.91\u20130.98), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Quantitative autofluorescence shows excellent repeatability and reliability as well as follow\u2010up agreement in patients with early and intermediate <jats:styled-content style=\"fixed-case\">AMD<\/jats:styled-content> without retinal changes. This is relevant when conducting longitudinal studies using <jats:styled-content style=\"fixed-case\">qAF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.13987","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T04:39:02Z","timestamp":1544762342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Repeatability and reliability of quantitative fundus autofluorescence imaging in patients with early and intermediate age\u2010related macular degeneration"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7661-4015","authenticated-orcid":false,"given":"Gregor Sebastian","family":"Reiter","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-7081","authenticated-orcid":false,"given":"Reinhard","family":"Told","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Baratsits","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hecht","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand Georg","family":"Schlanitz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sacu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Schmidt\u2010Erfurth","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry Vienna Trial Center (VTC) Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12250"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301547"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14802"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16274"},{"key":"e_1_2_5_6_1","first-page":"31","article-title":"Cell death in age\u2010related macular degeneration","volume":"5","author":"Adler R","year":"1999","journal-title":"Mol Vis"},{"key":"e_1_2_5_7_1","first-page":"e53577","article-title":"Quantitative fundus autofluorescence for the evaluation of retinal diseases","volume":"109","author":"Armenti ST","year":"2016","journal-title":"J Vis Exp"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5256"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800204"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13624"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.6636"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060119035"},{"key":"e_1_2_5_14_1","first-page":"1236","article-title":"Photoreceptor loss in age\u2010related macular degeneration","volume":"37","author":"Curcio CA","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.05.016"},{"key":"e_1_2_5_16_1","first-page":"1855","article-title":"Age\u2010related accumulation and spatial distribution of lipofuscin in RPE of normal subjects","volume":"42","author":"Delori FC","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8319"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13834"},{"key":"e_1_2_5_19_1","first-page":"583","article-title":"Lipofuscin and melanin of human retinal pigment epithelium. 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