{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:36:06Z","timestamp":1778200566099,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Kayser\u2013Fleischer ring pathognomonic for Wilson disease (<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit\u2010lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle view is obscured by the corneal limbus. The aim of the research was to evaluate the anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>), as objective diagnostic assessment of copper deposits forming <jats:styled-content style=\"fixed-case\">KF<\/jats:styled-content> ring in patients with <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine subjects (17 women) and twenty\u2010nine controls (14 women) were enrolled and underwent slit lamp and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Kayser\u2013Fleischer ring was not detected \u2013 either with a slit lamp or with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> \u2013 in any of the controls. Fifteen subjects presenting without <jats:styled-content style=\"fixed-case\">KF<\/jats:styled-content> ring at a slit\u2010lamp examination were found to have a <jats:styled-content style=\"fixed-case\">KF<\/jats:styled-content> ring when examined with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> (p<jats:italic>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), which confirms improved accuracy of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>, as compared to the slit\u2010lamp examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> as a diagnostic procedure to offer better objectivity and accuracy as compared to a slit\u2010lamp examination, both at the diagnostic stage and when monitoring changes in <jats:styled-content style=\"fixed-case\">KF<\/jats:styled-content> ring during medical therapy to assess its efficacy and patient compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14009","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T07:18:52Z","timestamp":1547277532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Anterior segment optical coherence tomography (<scp>AS<\/scp>\u2010<scp>OCT<\/scp>) as a new method of detecting copper deposits forming the Kayser\u2013Fleischer ring in patients with Wilson disease"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-0496","authenticated-orcid":false,"given":"Karina","family":"Broniek\u2010Kowalik","sequence":"first","affiliation":[{"name":"SPKSO Ophthalmic University Hospital Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Dzie\u017cyc","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology Institute of Psychiatry and Neurology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Litwin","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology Institute of Psychiatry and Neurology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cz\u0142onkowska","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology Institute of Psychiatry and Neurology Warsaw Poland"},{"name":"Department of Experimental and Clinical Pharmacology Medical University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek P.","family":"Szaflik","sequence":"additional","affiliation":[{"name":"SPKSO Ophthalmic 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