{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:41:46Z","timestamp":1747183306796,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The scope of the study was the functional assessment of possible effects of intravitreally injected ocriplasmin using electroretinographical (<jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content>) examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven subjects suffered from pathologies within the label of ocriplasmin (Jetrea<jats:sup>\u00ae<\/jats:sup>) were examined in the study. An extended international society for clinical electrophysiology of vision <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content> protocol was used for baseline recordings (before treatment) and was repeated for comparison 3\u00a0months after treatment with intravitreally injected ocriplasmin. All subjects were examined using 6 steps and a 9\u00a0Hz flicker protocol as scotopic flicker response under dark\u2010adapted conditions. Under light\u2010adapted conditions, two single\u2010flash responses (standard flash and On\/Off protocol) and a 31\u00a0Hz flicker response was used for functional assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction of amplitudes was found for the lowest stimulation intensity (0.0001\u00a0cd.s\/m\u00b2) under dark\u2010adapted conditions after treatment (p\u00a0=\u00a00.027). All other parameters were not significantly different after treatment including the scotopic flicker response. Under light\u2010adapted state, the a\u2010 and b\u2010wave amplitudes were not significantly altered after treatment for single\u2010flash and flicker responses. The On\u2010 and Off\u2010responses were not significantly different between baseline and after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One single significant difference of all examined parameters mirrors a difference due to chance, even if a negative effect of proteolytic enzymes on laminin and fibronectin of retinal cells cannot be entirely excluded. Nevertheless, this result should be respected in order to ensure a safe use of ocriplasmin for patients with vitreoretinal disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14030","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T19:05:34Z","timestamp":1549566334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Ocriplasmin on objectively assessed retinal function after treatment of vitreomacular diseases"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-4518","authenticated-orcid":false,"given":"Andreas","family":"Schatz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Katharinenhospital Klinikum Stuttgart Stuttgart Germany"},{"name":"Centre for Ophthalmology University of T\u00fcbingen T\u00fcbingen 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