{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:32:26Z","timestamp":1790386346313,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Evidence exists that the interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201010 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 family cytokines <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201020, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201028A and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201029 in aqueous humour (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Aqueous humour (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>) samples from patients with active uveitis associated with Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a013), sarcoidosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010B27\u2010related inflammation (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), Vogt\u2013Koyanagi\u2013Harada (<jats:styled-content style=\"fixed-case\">VKH<\/jats:styled-content>) disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and control subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) were assayed with the use of a multiplex assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 family cytokines studied, only <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 levels were significantly higher in <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> samples of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a045) than in controls (p\u00a0=\u00a00.022). When comparing the four individual disease groups to controls, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 levels were only significantly higher in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis (p\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 levels were significantly higher in patients with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis than in patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, sarcoidosis and <jats:styled-content style=\"fixed-case\">VKH<\/jats:styled-content> disease (p\u00a0&lt;\u00a00.001; p\u00a0=\u00a00.002; p\u00a0&lt;\u00a00.001, respectively). Significant correlations were found between <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 and <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>, (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.3; p\u00a0=\u00a00.03) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.56; p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 family cytokines analysed, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 demonstrated the highest expression in endogenous uveitis, particularly in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201019 thus might assist in the regulation of inflammation in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27\u2010associated uveitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14039","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:33:10Z","timestamp":1550129590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression of interleukin (<scp>IL<\/scp>)\u201010 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of <scp>IL<\/scp>\u201019 in human leucocyte antigen\u2010B27\u2010associated uveitis"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-8617","authenticated-orcid":false,"given":"Ahmed M.","family":"Abu El\u2010Asrar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"},{"name":"Dr. Nasser Al\u2010Rashid Research Chair in Ophthalmology College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Berghmans","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research Department of Microbiology and Immunology University of Leuven KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Al\u2010Obeidan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology College of Medicine King Saud University Riyadh Saudi 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