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Accompanying changes in deeper corneal microarchitecture were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean central corneal thickness in 40 eyes with keratoconus at baseline was 482.7\u00a0\u00b1\u00a038.2\u00a0<jats:italic>\u03bc<\/jats:italic>m, while mean central epithelial thickness (<jats:styled-content style=\"fixed-case\">CET<\/jats:styled-content>) was 43.8\u00a0\u00b1\u00a06.4\u00a0<jats:italic>\u03bc<\/jats:italic>m. At the final visit 20\u00a0\u00b1\u00a05\u00a0days post\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> procedure, <jats:styled-content style=\"fixed-case\">CET<\/jats:styled-content> was 35.0\u00a0\u00b1\u00a05.8\u00a0<jats:italic>\u03bc<\/jats:italic>m, significantly thinner after reepithelization (p\u00a0&lt;\u00a00.001). Surgical success was assessed at the final visit through the demarcation line (<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>), identified at 43.7\u00a0\u00b1\u00a013.5% stromal depth. In rabbits, the mean <jats:styled-content style=\"fixed-case\">CET<\/jats:styled-content> in 20 eyes at baseline was 35.9\u00a0\u00b1\u00a02.6\u00a0<jats:italic>\u03bc<\/jats:italic>m. In rabbits that revealed complete wound closure (10\/20 eyes) at the last study day at 72\u00a0hr, <jats:styled-content style=\"fixed-case\">CET<\/jats:styled-content> was significantly thinner compared to baseline (30.4\u00a0\u00b1\u00a02.8\u00a0<jats:italic>\u03bc<\/jats:italic>m versus 35.4\u00a0\u00b1\u00a02.9\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0=\u00a00.005). An intra\u2010stromal landmark indicating early keratocyte apoptosis was measured at 30.0\u00a0\u00b1\u00a05.1% stromal depth. Epithelial thickness maps showed the time\u2013course of corneal healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrahigh\u2010resolution (<jats:styled-content style=\"fixed-case\">UHR<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> provided precise assessment of epithelial wound and its healing by 3D\u2010mapping. In addition, microarchitectural changes in the cornea in early phases of epithelial healing were revealed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14053","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T10:40:52Z","timestamp":1550140852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ultrahigh\u2010resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-0751","authenticated-orcid":false,"given":"Anca","family":"Pantalon","sequence":"first","affiliation":[{"name":"Center for Medical Physics and Biomedical Engineering Medical University of Vienna Vienna Austria"},{"name":"Department of Ophthalmology Gr. T. 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