{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:17:37Z","timestamp":1792581457695,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute optic neuritis (<jats:styled-content style=\"fixed-case\">AON<\/jats:styled-content>) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (<jats:styled-content style=\"fixed-case\">AMN<\/jats:styled-content>) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a first episode of optic neuritis were invited to participate in a study that involved optical coherence tomography evaluation at baseline and the following 1, 3, 6 and 12\u00a0months. All the study patients underwent ophthalmologic evaluation that comprised of visual acuity, visual field and multimodal imaging as well as orbital and brain Magnetic Resonance Imaging. A diagnosis of multiple sclerosis was made according to the 2010 McDonald criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of the 114 patients with acute optic neuritis also had acute macular neuroretinopathy, of whom three were positive for myelin oligodendrocyte glycoprotein antibodies (<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010Abs), two had relapsing\u2013remitting multiple sclerosis and one had clinical isolated syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that it is imperative to check for associated<jats:styled-content style=\"fixed-case\">AMN<\/jats:styled-content>in cases of<jats:styled-content style=\"fixed-case\">AON<\/jats:styled-content>, especially those associated with<jats:styled-content style=\"fixed-case\">MOG<\/jats:styled-content>\u2010Abs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14054","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:24:56Z","timestamp":1550129096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A new association: acute macular neuroretinopathy in acute optic neuritis"],"prefix":"10.1111","volume":"97","author":[{"given":"Romain","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Clinical Research Department Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Shor","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vignal","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Ophthalmolology Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Salomon","sequence":"additional","affiliation":[{"name":"Clinical Research Department Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gout","sequence":"additional","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-9397","authenticated-orcid":false,"given":"Martine","family":"Mauget\u2010Fa\u00ffsse","sequence":"additional","affiliation":[{"name":"Clinical Research Department Fondation Ophtalmologique Adolphe de Rothschild Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000172"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.03.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8615-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-0024-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"e0184927","DOI":"10.1371\/journal.pone.0184927","article-title":"Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases","volume":"12","author":"Chen TC","year":"2017","journal-title":"PLoS ONE"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13315"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318263d0c3"},{"key":"e_1_2_6_9_1","first-page":"9","article-title":"Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis","volume":"135245851775000","author":"Feucht N","year":"2018","journal-title":"Mult Scler"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq080"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000414"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.3760\/cma.j.issn.0366-6999.20130960","article-title":"Clinical features of retinal diseases masquerading as retrobulbar optic neuritis","volume":"126","author":"Jiang LB","year":"2013","journal-title":"Chin Med J"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315619494"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2018.02.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-306845"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.10.026"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30278-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000785"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.4056"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000048"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faos.14054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T19:43:53Z","timestamp":1720986233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/aos.14054"],"URL":"https:\/\/doi.org\/10.1111\/aos.14054","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]},"assertion":[{"value":"2018-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}