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The patients were divided into three groups according to the fluorescein angiograghy (\n FFA<\/jats:styled-content>\n ): central retinal vein occlusion (\n CRVO<\/jats:styled-content>\n ) group (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 15), branch retinal vein occlusion (\n BRVO<\/jats:styled-content>\n ) group (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 15) and\n NVG<\/jats:styled-content>\n group (secondary to\n CRVO<\/jats:styled-content>\n ,\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 11). The patients who had undergone cataract surgery (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 16) during the same period served as controls. The\n SEMA<\/jats:styled-content>\n 3A concentration in aqueous humor collected before the initial anti\u2010\n VEGF<\/jats:styled-content>\n injection was determined by enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ). Central retinal thickness (\n CRT<\/jats:styled-content>\n ), cube volume (\n CV<\/jats:styled-content>\n ) and ganglion cell\u2010inner plexiform layer (\n GC<\/jats:styled-content>\n \u2010\n IPL<\/jats:styled-content>\n ) thickness was analysed by spectral\u2010domain optical coherence tomography (\n SD<\/jats:styled-content>\n \u2010\n OCT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Semaphorin 3A level in\n CRVO<\/jats:styled-content>\n group (1.52\u00a0\u00b1\u00a01.23\u00a0ng\/ml) and\n NVG<\/jats:styled-content>\n group (1.67\u00a0\u00b1\u00a00.98\u00a0ng\/ml) were significantly higher than the control group (0.66 \u00b1 0.58\u00a0ng\/ml; both p\n \u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05). Moreover,\n SEMA<\/jats:styled-content>\n 3A level in\n CRVO<\/jats:styled-content>\n group was higher than\n BRVO<\/jats:styled-content>\n group (1.52\u00a0\u00b1\u00a01.23\u00a0ng\/ml versus 0.53\u00a0\u00b1\u00a00.37\u00a0ng\/ml; p\n \u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05).\n SEMA<\/jats:styled-content>\n 3A level was positively correlated with\n CRT<\/jats:styled-content>\n and\n CV<\/jats:styled-content>\n in both\n BRVO<\/jats:styled-content>\n group (\n CRT<\/jats:styled-content>\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.6535, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0082;\n CV<\/jats:styled-content>\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.5190, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0474) and\n CRVO<\/jats:styled-content>\n group (\n CRT<\/jats:styled-content>\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.6270, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0124;\n CV<\/jats:styled-content>\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.6898, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0044). In\n RVO<\/jats:styled-content>\n patients, the\n GC<\/jats:styled-content>\n \u2010\n IPL<\/jats:styled-content>\n thickness of affected eyes were significantly reduced compared with the normal follow eyes (\n CRVO<\/jats:styled-content>\n t\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 4.55, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.006;\n BRVO<\/jats:styled-content>\n t\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 4.54, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.004). Meanwhile, negative correlation of\n SEMA<\/jats:styled-content>\n 3A level with\n GC<\/jats:styled-content>\n \u2010\n IPL<\/jats:styled-content>\n thickness was found in both\n BRVO<\/jats:styled-content>\n group (\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.5906, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0205) and\n CRVO<\/jats:styled-content>\n group (\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.6100, p\n \u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0157).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Semaphorin 3A level is increased in aqueous humor of\n RVO<\/jats:styled-content>\n patients. Positive correlation of\n CRT<\/jats:styled-content>\n as well as negative correlation of\n GC<\/jats:styled-content>\n \u2010\n IPL<\/jats:styled-content>\n thickness with\n SEMA<\/jats:styled-content>\n 3A may suggest a pathological role of\n SEMA<\/jats:styled-content>\n 3A in macular oedema and ganglion cell degeneration during\n RVO<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.14079","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T01:17:17Z","timestamp":1551143837000},"page":"273-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion"],"prefix":"10.1111","volume":"97","author":[{"given":"Shengxiang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology First Affiliated 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