{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:39:54Z","timestamp":1790789994835,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the annual incidence rate of keratoconus in Denmark 1995\u20132015 and prevalence of keratoconus in the National Danish Patient Register 1977\u20132015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients diagnosed with keratoconus in the National Danish Patient Register 1977\u20132015 were included in the study. The annual incidence rates and the overall prevalence of diagnosed keratoconus in the register were calculated using life tables from the general Danish population. A sub\u2010analysis excluding immigrants and descendants was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An increase in the annual incidence rate was seen from 1.24 per 100\u00a0000 person\u2010years in 2003 to 3.83 per 100\u00a0000 in 2011. The average incidence rate 2011\u20132015 was 3.60 per 100\u00a0000 person\u2010years. A survey of primary\u2010sector ophthalmologists supported that the register data could be considered complete from 2011. The prevalence of diagnosed keratoconus in the National Patient Register 1977\u20132015 was 44 per 100\u00a0000 persons. Excluding immigrants and descendants yielded an average incidence rate 2011\u20132015 of 2.89 per 100\u00a0000 person\u2010years and a prevalence of diagnosed keratoconus in the National Patient Register 1977\u20132015 of 40 per 100\u00a0000 persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present incidence rate (based on 2011\u20132015 data) has increased 2\u20133\u2010fold during the last 10\u201315\u00a0years. The increase is possibly largely a consequence of more complete data due to the availability of corneal cross\u2010linking, which has changed the referral pattern from the primary sector. Other factors such as better diagnostic tools and immigration may also play a role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14082","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T05:05:20Z","timestamp":1554786320000},"page":"752-755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Incidence and prevalence of keratoconus in Denmark \u2013 an update"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-9072","authenticated-orcid":false,"given":"Sashia","family":"Bak\u2010Nielsen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H.","family":"Ramlau\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Public Health \u2013 Section\u00a0for Epidemiology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ivarsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleguer","family":"Plana\u2010Ripoll","sequence":"additional","affiliation":[{"name":"National Center for Register\u2010based Research Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hjortdal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.12.015"},{"key":"e_1_2_5_3_1","first-page":"38","article-title":"[Epidemiology of keratoconus in the Urals]","volume":"114","author":"Gorskova EN","year":"1998","journal-title":"Vestn oftalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12147"},{"key":"e_1_2_5_5_1","first-page":"1","article-title":"Clinical and epidemiological features of keratoconus. 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