{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:37:11Z","timestamp":1791916631686,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the diurnal variations in peripapillary and macular flow density (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>), as measured using optical coherence tomography angiography (<jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content>) and to elaborate on the relationship between diurnal <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, circulatory parameters and intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) variations in primary open\u2010angle glaucoma (POAG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty eyes of 40 POAG patients were drawn into this cross\u2010sectional study. The retinal microvasculature of the macula (superficial and deep layers) and optic nerve [radial peripapillary capillary (<jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>)] was examined by <jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content> (AngioVue<jats:sup>\u00ae<\/jats:sup>, Optovue). Optical coherence tomography angiography (<jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content>) measurements were conducted at 08:00, 11:00, 15:00 and 20:00 over the course of two consecutive days. Intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) and circulatory parameters were assessed accordingly. Diurnal variations in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> were analysed using linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While superficial macular <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RPC FD<\/jats:styled-content> revealed not to be affected by diurnal variations (p\u00a0=\u00a00.492, p\u00a0=\u00a00.319), <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> in the deep layer of the macula increased throughout the day (p\u00a0&lt;\u00a00.001). Superficial macular <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> was influenced significantly by mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) (p\u00a0=\u00a00.006) and heart rate (HR) (p\u00a0=\u00a00.033), whereas <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content> layer was significantly affected by <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> (p\u00a0=\u00a00.010). No statistically significant effect of <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> fluctuations on <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows diurnal fluctuations of deep macular <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> measured by <jats:styled-content style=\"fixed-case\">OCTA<\/jats:styled-content> and outlines the relationship between <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and hemodynamic parameters (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) in POAG patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14089","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T09:09:24Z","timestamp":1553245764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diurnal variations in flow density measured using optical coherence tomography angiography and the impact of heart rate, mean arterial pressure and intraocular pressure on flow density in primary open\u2010angle glaucoma patients"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-8043","authenticated-orcid":false,"given":"Viktoria Constanze","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Julian","family":"Storp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kerschke","sequence":"additional","affiliation":[{"name":"Department of Biometry and Clinical Research University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Nelis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Eter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Alnawaiseh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Muenster Medical Centre Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001419"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3865-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2890357"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5896"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.6.449"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161631"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000527"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000519"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.021"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70127-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6956717"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2015.2225"},{"key":"e_1_2_5_16_1","first-page":"1","article-title":"Optical coherence tomography angiography and glaucoma: searching for the missing link","volume":"6","author":"Mansouri K","year":"2016","journal-title":"Expert Rev Med Devices"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000914"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.10.001"},{"key":"e_1_2_5_19_1","unstructured":"R Core Team(2017):R: A language and environment for statistical computing.Vienna Austria:R Foundation for Statistical Computing. 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