{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:23:02Z","timestamp":1793294582969,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the efficacy and safety of collagen matrix implant (Ologen<jats:sup>\u00ae<\/jats:sup>; <jats:styled-content style=\"fixed-case\">OLO<\/jats:styled-content>) with mitomycin C (<jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>) in phacotrabeculectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, single\u2010centre, nonblinded, randomized controlled trial. A total of 53 eyes of 45 patients were enrolled in the study protocol with 27 eyes randomly assigned to <jats:styled-content style=\"fixed-case\">OLO<\/jats:styled-content> and 26 to <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>. The follow\u2010up was 12\u00a0months. The primary outcome measure was mean change from baseline intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>) in both groups after 12\u00a0months. The secondary outcome measures were cumulative success rates at 12\u00a0months with Kaplan\u2013Meier analysis, change in number of medications, change in best corrected visual acuity (<jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>), and bleb morphology assessed using Moorfields Bleb Grading System and anterior segment swept\u2010source optical coherence tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content> decreased from 26.4\u00a0\u00b1\u00a06.1\u00a0mmHg to 13.7\u00a0\u00b1\u00a03.8 in the <jats:styled-content style=\"fixed-case\">OLO<\/jats:styled-content> group and from 23.4\u00a0\u00b1\u00a03.6\u00a0mmHg to 13.3\u00a0\u00b1\u00a02.8 in the <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> group at 1\u00a0year without significant intergroup differences. At 1\u00a0year, the overall success rates were 92.6% and 92.3% in the <jats:styled-content style=\"fixed-case\">OLO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> groups, respectively. There were no significant differences in the overall success rates, <jats:styled-content style=\"fixed-case\">BCVA<\/jats:styled-content>, number of medications, morphology of the filtering blebs and rate of complications at the end of the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ologen (OLO) provides similar surgical outcomes in phacotrabeculectomy compared with adjunctive MMC. It may be a new, safe and effective alternative to <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content> for combined phacoemulsification and trabeculectomy surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14102","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:24:51Z","timestamp":1553862291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Phacotrabeculectomy using collagen matrix implant (Ologen<sup>\u00ae<\/sup>) versus mitomycin C: a prospective randomized controlled trial"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-7883","authenticated-orcid":false,"given":"Aleksandra","family":"Wla\u017a","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Microsurgery of Glaucoma Medical University Lublin 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