{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:42:22Z","timestamp":1773855742747,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the detection of different lesions of diabetic retinopathy (<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>) in scanning laser ophthalmoscopy (<jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content>) compared to colour fundus photographs within the same retinal field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scanning laser ophthalmoscopy and colour fundus photographs of 67 eyes taken on the same day of dilated patients with different grades of diabetic retinopathy were retrospectively examined. <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> images were then cropped to match the size and position of its 45\u2010degree colour fundus photograph equivalent. Five independent masked graders assessed the images. Features of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> including haemorrhages, microaneurysms, exudates, cotton wool spots, intraretinal microvascular abnormalities, venous beading and neovascularization were analysed. Additionally, each image was classified according to Early Treatment of Diabetic Retinopathy Study (<jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content>) grading and English Diabetic Eye Screening Programme (<jats:styled-content style=\"fixed-case\">DESP<\/jats:styled-content>) grading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was moderate to good agreement in <jats:styled-content style=\"fixed-case\">ETDRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DESP<\/jats:styled-content> grading between <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> and colour fundus photographs within individual graders (weighted kappa range 0.45\u20130.65). The average number of microaneurysms for <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> and colour photographs showed a high degree of agreement (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>: 0.92). Equally, the average number of blot haemorrhages in <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> and colour images showed strong agreement (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>: 0.98) and the average number of cotton wool spots in <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> and colour images correlated well (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>: 0.92). For these three lesions, the intergrader reliability was good (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> \u22650.66) for both modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was good correlation in detected microaneurysms, blot haemorrhages and cotton wool spots between <jats:styled-content style=\"fixed-case\">SLO<\/jats:styled-content> and colour fundus photographs. However, there was intergrader variability in flame haemorrhage, intraretinal microvascular abnormalities, venous beading and neovascularization grading with both modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14106","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T06:24:20Z","timestamp":1562653460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparing diabetic retinopathy lesions in scanning laser ophthalmoscopy and colour fundus photography"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-1183","authenticated-orcid":false,"given":"Allan Zhifa","family":"Nghiem","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Nderitu","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital London 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