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Images processing of <jats:styled-content style=\"fixed-case\">TMIS<\/jats:styled-content> included filtration, recognition and measurement of slit lamp photographs under certain algorithm, which output two measurement patterns, <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ax<\/jats:sub> and <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ean<\/jats:sub>. <jats:styled-content style=\"fixed-case\">TMH<\/jats:styled-content> measured by ImageJ software, considered as the reference value, was conducted by a masked observer while four masked ophthalmologists performed the manual evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both magnifications, <jats:styled-content style=\"fixed-case\">TMH<\/jats:styled-content> measured by <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ean<\/jats:sub> showed similar values with ImageJ while manual evaluation demonstrated underestimated results, and a strong correlation was detected between <jats:styled-content style=\"fixed-case\">TMIS<\/jats:styled-content> and ImageJ. In \u00d716 magnified photographs, manually obtained <jats:styled-content style=\"fixed-case\">TMH<\/jats:styled-content> revealed a higher correlation with ImageJ, whereas a notably stronger correlation of <jats:styled-content style=\"fixed-case\">TMIS<\/jats:styled-content> with ImageJ was observed in \u00d740 photographs. Correspondingly, the accuracy for both <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ax<\/jats:sub> and <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ean<\/jats:sub> appeared to be lower than most doctors in \u00d716 slit lamp images, in contrast to a better precision of <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ean<\/jats:sub> in \u00d740 ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new software displayed high accuracy and efficacy in \u00d740 magnification and <jats:styled-content style=\"fixed-case\">TMIS<jats:sub>M<\/jats:sub><\/jats:styled-content><jats:sub>ean<\/jats:sub> pattern, suggesting the possibility of this automated <jats:styled-content style=\"fixed-case\">TMH<\/jats:styled-content> measurement platform to be a valid tool in dry eye screening and follow\u2010up 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